Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

PCGF2

contributors: mct/npt - updated : 06-12-2018

HGNC name	polycomb group ring finger 2
HGNC id	12929

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

CFNCS

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in breast cancer tumoral       loss of function contributes to the hormone-independent phenotype of breast cancer by modulating hormone receptor expression tumoral     --low   might contribute to the Colorectal cancer development/progression

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	its expression is a marker for determining the antihormonal therapy response in patients with breast cancer
Therapy target
	System Type Disorder Pubmed cancer reproductive prostate possible therapeutic target, as well as a diagnostic marker for poor prognosis in prostate cancer patients

ANIMAL & CELL MODELS

Knock-out mice suggest that the protein may negatively regulate expression of different cytokines, chemokines, and chemokine receptors