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FLASH GENE
Symbol PCGF2 contributors: mct/npt - updated : 06-12-2018
HGNC name polycomb group ring finger 2
HGNC id 12929
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N-terminal RING finger (C3HC4 type) domain, not required for its interaction with RANGAP1 or its ability to inhibit RANGAP1 sumoylation
  • a pro/ser rich region
  • a nuclear localization signal
    • HOMOLOGY
    interspecies homolog to murine Zfp144
    homolog to rattus LOC287662
    Homologene
    FAMILY
  • MEL18/BMI1 zinc finger protein family
    • CATEGORY transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • transcriptional repressor
  • ubiquitin ligase activity
  • playing a role in thymic T cell migration and differentiation via the chemokine system
  • functions as an anti-SUMO E3 factor, and extend its targets to include regulation of the sumoylation of the important cellular protein RANGAP1
  • regulates angiogenic genes including kinase insert domain receptor (KDR), claudin 5, and angiopoietin-like 2
  • plays a significant role in the angiogenic function of endothelial cells (ECs) by regulating endothelial gene expression
  • expressed during endothelial precursor cells differentiation and plays an important and unique role as a transcriptional regulator of multiple proteins important for EC function
  • implicated in several processes in tumor progression, in which the Akt pathway is involved as an important key molecular event
  • regulator of tumor angiogenesis through regulating HIF1A and its target VEGF expressions mediated by the PTEN/PI3K/Akt pathway, suggesting a new tumor-suppressive role in breast cancer
  • PCGF2, a PRC1 gene, played a negative role in the granulocytic differentiation of acute promyelocytic leukemia (APL) cells
  • BMI1 and PCGF2 have opposing functions and are present in distinct complexes
  • involved in cancer stem cell (CSC) regulation
  • negative regulator of breast CSCs that inhibits the stem cell population and in vitro and in vivo self-renewal through the inactivation of Wnt-mediated NOTCH signaling
  • is a SUMO-dependent regulator of hormone receptors
  • encodes the polycomb group ring finger 2 protein, a transcriptional repressor involved in cell proliferation, differentiation, and embryogenesis
  • important role of PCGF2 in human development
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the polycomb repressive complex 1 (PRC1), a multiprotein complex which controls gene silencing through histone modification and chromatin remodelling
    • INTERACTION
    DNA binding to the specific sequence 5'-GACTNGACT-3'
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • binds to a protein called HSF2 and inhibits HSF2 sumoylation, thereby functioning as an anti-SUMO E3 factor
  • interacts with the RANGAP1 protein and inhibits its sumoylation, and these activities do not require its RING domain
  • interaction with HSF2 decreases during mitosis, resulting in elevated PCGF2 sumoylation
  • interaction with the SUMO E2 enzyme UBE2I, likely important for the sumoylation-inhibitory function of PCGF2
  • novel regulator of HIF1A (regulated the HIF1A expression and activity via the PI3K/Akt pathway
  • PCGF2 binds directly to CCND2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CFNCS
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer
    tumoral       loss of function
    contributes to the hormone-independent phenotype of breast cancer by modulating hormone receptor expression
    tumoral     --low  
    might contribute to the Colorectal cancer development/progression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • its expression is a marker for determining the antihormonal therapy response in patients with breast cancer
    • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    possible therapeutic target, as well as a diagnostic marker for poor prognosis in prostate cancer patients
    ANIMAL & CELL MODELS
    Knock-out mice suggest that the protein may negatively regulate expression of different cytokines, chemokines, and chemokine receptors