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FLASH GENE
Symbol PCGF2 contributors: mct/npt - updated : 06-12-2018
HGNC name polycomb group ring finger 2
HGNC id 12929
Corresponding disease
CFNCS craniofacial, neurological, cardiovascular, and skeletal syndrome
Location 17q12      Physical location : 36.890.149 - 36.904.558
Synonym name
  • zinc finger protein 144 (Mel-18)
  • ring finger protein 110
  • DNA-binding protein Mel-18
    • Synonym symbol(s) MEL18, ZNF144, RNF110, MGC10545, MEL-18
    DNA
    TYPE functioning gene
    STRUCTURE 15.92 kb     11 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 2622 37.6 344 - 2015 25822021
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Nervousbrain     Homo sapiens
    Reproductivefemale systemplacenta  highly
    Respiratorylung   highly
    Urinarykidney   highly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiensFetal
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N-terminal RING finger (C3HC4 type) domain, not required for its interaction with RANGAP1 or its ability to inhibit RANGAP1 sumoylation
  • a pro/ser rich region
  • a nuclear localization signal
    • HOMOLOGY
    interspecies homolog to murine Zfp144
    homolog to rattus LOC287662
    Homologene
    FAMILY
  • MEL18/BMI1 zinc finger protein family
    • CATEGORY transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • transcriptional repressor
  • ubiquitin ligase activity
  • playing a role in thymic T cell migration and differentiation via the chemokine system
  • functions as an anti-SUMO E3 factor, and extend its targets to include regulation of the sumoylation of the important cellular protein RANGAP1
  • regulates angiogenic genes including kinase insert domain receptor (KDR), claudin 5, and angiopoietin-like 2
  • plays a significant role in the angiogenic function of endothelial cells (ECs) by regulating endothelial gene expression
  • expressed during endothelial precursor cells differentiation and plays an important and unique role as a transcriptional regulator of multiple proteins important for EC function
  • implicated in several processes in tumor progression, in which the Akt pathway is involved as an important key molecular event
  • regulator of tumor angiogenesis through regulating HIF1A and its target VEGF expressions mediated by the PTEN/PI3K/Akt pathway, suggesting a new tumor-suppressive role in breast cancer
  • PCGF2, a PRC1 gene, played a negative role in the granulocytic differentiation of acute promyelocytic leukemia (APL) cells
  • BMI1 and PCGF2 have opposing functions and are present in distinct complexes
  • involved in cancer stem cell (CSC) regulation
  • negative regulator of breast CSCs that inhibits the stem cell population and in vitro and in vivo self-renewal through the inactivation of Wnt-mediated NOTCH signaling
  • is a SUMO-dependent regulator of hormone receptors
  • encodes the polycomb group ring finger 2 protein, a transcriptional repressor involved in cell proliferation, differentiation, and embryogenesis
  • important role of PCGF2 in human development
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the polycomb repressive complex 1 (PRC1), a multiprotein complex which controls gene silencing through histone modification and chromatin remodelling
    • INTERACTION
    DNA binding to the specific sequence 5'-GACTNGACT-3'
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • binds to a protein called HSF2 and inhibits HSF2 sumoylation, thereby functioning as an anti-SUMO E3 factor
  • interacts with the RANGAP1 protein and inhibits its sumoylation, and these activities do not require its RING domain
  • interaction with HSF2 decreases during mitosis, resulting in elevated PCGF2 sumoylation
  • interaction with the SUMO E2 enzyme UBE2I, likely important for the sumoylation-inhibitory function of PCGF2
  • novel regulator of HIF1A (regulated the HIF1A expression and activity via the PI3K/Akt pathway
  • PCGF2 binds directly to CCND2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CFNCS
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer
    tumoral       loss of function
    contributes to the hormone-independent phenotype of breast cancer by modulating hormone receptor expression
    tumoral     --low  
    might contribute to the Colorectal cancer development/progression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • its expression is a marker for determining the antihormonal therapy response in patients with breast cancer
    • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    possible therapeutic target, as well as a diagnostic marker for poor prognosis in prostate cancer patients
    ANIMAL & CELL MODELS
    Knock-out mice suggest that the protein may negatively regulate expression of different cytokines, chemokines, and chemokine receptors