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FLASH GENE

Symbol

PCGF2

contributors: mct/npt - updated : 06-12-2018

HGNC name	polycomb group ring finger 2
HGNC id	12929

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_007144 11 - 2622 NP_009075 37.6 344 - 2015 25822021

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive salivary gland       highly Nervous brain         Homo sapiens Reproductive female system placenta     highly Respiratory lung       highly Urinary kidney       highly Visual eye       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron Homo sapiens Fetal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N-terminal RING finger (C3HC4 type) domain, not required for its interaction with RANGAP1 or its ability to inhibit RANGAP1 sumoylation
	a pro/ser rich region
	a nuclear localization signal

HOMOLOGY

interspecies	homolog to murine Zfp144
	homolog to rattus LOC287662

Homologene

FAMILY

MEL18/BMI1 zinc finger protein family

CATEGORY

transcription factor , tumor suppressor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleoplasm,nuclear bodies
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	transcriptional repressor
	ubiquitin ligase activity
	playing a role in thymic T cell migration and differentiation via the chemokine system
	functions as an anti-SUMO E3 factor, and extend its targets to include regulation of the sumoylation of the important cellular protein RANGAP1
	regulates angiogenic genes including kinase insert domain receptor (KDR), claudin 5, and angiopoietin-like 2
	plays a significant role in the angiogenic function of endothelial cells (ECs) by regulating endothelial gene expression
	expressed during endothelial precursor cells differentiation and plays an important and unique role as a transcriptional regulator of multiple proteins important for EC function
	implicated in several processes in tumor progression, in which the Akt pathway is involved as an important key molecular event
	regulator of tumor angiogenesis through regulating HIF1A and its target VEGF expressions mediated by the PTEN/PI3K/Akt pathway, suggesting a new tumor-suppressive role in breast cancer
	PCGF2, a PRC1 gene, played a negative role in the granulocytic differentiation of acute promyelocytic leukemia (APL) cells
	BMI1 and PCGF2 have opposing functions and are present in distinct complexes
	involved in cancer stem cell (CSC) regulation
	negative regulator of breast CSCs that inhibits the stem cell population and in vitro and in vivo self-renewal through the inactivation of Wnt-mediated NOTCH signaling
	is a SUMO-dependent regulator of hormone receptors
	encodes the polycomb group ring finger 2 protein, a transcriptional repressor involved in cell proliferation, differentiation, and embryogenesis
	important role of PCGF2 in human development

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component of the polycomb repressive complex 1 (PRC1), a multiprotein complex which controls gene silencing through histone modification and chromatin remodelling

INTERACTION

DNA	binding to the specific sequence 5'-GACTNGACT-3'

RNA

small molecule	metal binding,
	Zn2+

protein	binds to a protein called HSF2 and inhibits HSF2 sumoylation, thereby functioning as an anti-SUMO E3 factor
	interacts with the RANGAP1 protein and inhibits its sumoylation, and these activities do not require its RING domain
	interaction with HSF2 decreases during mitosis, resulting in elevated PCGF2 sumoylation
	interaction with the SUMO E2 enzyme UBE2I, likely important for the sumoylation-inhibitory function of PCGF2
	novel regulator of HIF1A (regulated the HIF1A expression and activity via the PI3K/Akt pathway
	PCGF2 binds directly to CCND2

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

CFNCS

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in breast cancer tumoral       loss of function contributes to the hormone-independent phenotype of breast cancer by modulating hormone receptor expression tumoral     --low   might contribute to the Colorectal cancer development/progression

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	its expression is a marker for determining the antihormonal therapy response in patients with breast cancer
Therapy target
	System Type Disorder Pubmed cancer reproductive prostate possible therapeutic target, as well as a diagnostic marker for poor prognosis in prostate cancer patients

ANIMAL & CELL MODELS

Knock-out mice suggest that the protein may negatively regulate expression of different cytokines, chemokines, and chemokine receptors