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FLASH GENE

Symbol

LGMN

contributors: mct - updated : 07-12-2013

HGNC name	legumain
HGNC id	9472

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in response to hypoxic stress on mammary adenocarcinoma, colorectal cancer, proliferating endothelial cells, and tumor-associated macrophages (TAMs) tumoral     --over   correlates with increased cell migration and invasion of ovarian cancer cells

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	potential biomarker for treatment of ovarian cancer
Therapy target
	System Type Disorder Pubmed cancer reproductive ovary molecular target for treatment of ovarian cancer diabete type 1   can serve as novel targets in diabetes mellitus genetic therapy

ANIMAL & CELL MODELS