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FLASH GENE

Symbol

LGMN

contributors: mct - updated : 07-12-2013

HGNC name	legumain
HGNC id	9472

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	14q32.12      Physical location : 93.170.151 - 93.215.047
Synonym name	asparaginyl endopeptidase
	protease, cysteine, 1 (legumain)
Synonym symbol(s)	PRSC1, AEP, LGMN1
EC.number	3.4.22.34

DNA

TYPE	functioning gene
STRUCTURE	44.90 kb     13 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	Binding site
text structure	a TP53-binding site in intron 1 of the human legumain gene

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005606 14 - 2073 NP_005597 - 433 - - NM_001008530 15 - 2191 NP_001008530 - 433 - -

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen       highly Cardiovascular heart       predominantly Digestive liver         Endocrine pancreas         Nervous brain         Reproductive male system prostate       Respiratory lung         Urinary kidney       predominantly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text	predominantly in placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

GlycoP

HOMOLOGY

interspecies	homolog to Schistosoma japonicum hemoglobinase
	homolog to murine Lgmn
	homolog to C.elegans W04G3.5

Homologene

FAMILY	protease subfamily C, cysteine, peptidase family C13
	asparaginyl endopeptidase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,lumen
	intracellular,cytoplasm,organelle,endosome
	intracellular,cytoplasm,organelle,lysosome
	intracellular,nucleus
text	is thought to be located and processed towards its active form primarily in the endo-lysosomes
	endo-lysosomal and nuclear localizations

basic FUNCTION	having a strict specificity for hydrolysis of asparaginyl bonds (asparagine endopeptidase)
	can also cleave aspartyl bonds slowly, especially under acidic conditions
	may play a functional role in atherogenesis
	might contribute to the invasiveness and aggressiveness of prostate cancer
	may be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system
	cysteine protease legumain is involved in several biological and pathological processes
	asparaginyl endopeptidase highly expressed in tumors

CELLULAR PROCESS

protein, degradation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	can directly cleave TARDBP at seven sites, including N291 and N306
	legumain (LGMN) expression and its enzyme activity are regulated by TP53

cell & other

REGULATION

inhibited by

iodoacetamide,maleimides,ovocystatin and cystatin C

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in response to hypoxic stress on mammary adenocarcinoma, colorectal cancer, proliferating endothelial cells, and tumor-associated macrophages (TAMs) tumoral     --over   correlates with increased cell migration and invasion of ovarian cancer cells

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	potential biomarker for treatment of ovarian cancer
Therapy target
	System Type Disorder Pubmed cancer reproductive ovary molecular target for treatment of ovarian cancer diabete type 1   can serve as novel targets in diabetes mellitus genetic therapy

ANIMAL & CELL MODELS