SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,lumen
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| intracellular,cytoplasm,organelle,endosome
|
| intracellular,cytoplasm,organelle,lysosome
|
| intracellular,nucleus
|
text
| is thought to be located and processed towards its active form primarily in the endo-lysosomes |
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endo-lysosomal and nuclear localizations |
basic FUNCTION
| having a strict specificity for hydrolysis of asparaginyl bonds (asparagine endopeptidase) |
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can also cleave aspartyl bonds slowly, especially under acidic conditions |
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may play a functional role in atherogenesis |
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might contribute to the invasiveness and aggressiveness of prostate cancer |
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may be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system |
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cysteine protease legumain is involved in several biological and pathological processes |
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asparaginyl endopeptidase highly expressed in tumors |