Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol LGMN contributors: mct - updated : 07-12-2013
HGNC name legumain
HGNC id 9472
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 2073 - 433 - -
15 - 2191 - 433 - -
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   highly
Cardiovascularheart   predominantly
Digestiveliver    
Endocrinepancreas    
Nervousbrain    
Reproductivemale systemprostate   
Respiratorylung    
Urinarykidney   predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text predominantly in placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
interspecies homolog to Schistosoma japonicum hemoglobinase
homolog to murine Lgmn
homolog to C.elegans W04G3.5
Homologene
FAMILY
  • protease subfamily C, cysteine, peptidase family C13
  • asparaginyl endopeptidase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    intracellular,nucleus
    text
  • is thought to be located and processed towards its active form primarily in the endo-lysosomes
  • endo-lysosomal and nuclear localizations
  • basic FUNCTION
  • having a strict specificity for hydrolysis of asparaginyl bonds (asparagine endopeptidase)
  • can also cleave aspartyl bonds slowly, especially under acidic conditions
  • may play a functional role in atherogenesis
  • might contribute to the invasiveness and aggressiveness of prostate cancer
  • may be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system
  • cysteine protease legumain is involved in several biological and pathological processes
  • asparaginyl endopeptidase highly expressed in tumors
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • can directly cleave TARDBP at seven sites, including N291 and N306
  • legumain (LGMN) expression and its enzyme activity are regulated by TP53
  • cell & other
    REGULATION
    inhibited by iodoacetamide,maleimides,ovocystatin and cystatin C
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in response to hypoxic stress on mammary adenocarcinoma, colorectal cancer, proliferating endothelial cells, and tumor-associated macrophages (TAMs)
    tumoral     --over  
    correlates with increased cell migration and invasion of ovarian cancer cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • potential biomarker for treatment of ovarian cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveovary
    molecular target for treatment of ovarian cancer
    diabetetype 1 
    can serve as novel targets in diabetes mellitus genetic therapy
    ANIMAL & CELL MODELS