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FLASH GENE

Symbol

PTGIR

contributors: mct/shn - updated : 12-07-2012

HGNC name	prostaglandin I2 (prostacyclin) receptor (IP)
HGNC id	9602

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	disruption of the prostacyclin receptor gene in mice leads to increased susceptibility to thrombosis and reduced levels in inflammatory and pain responses
	injury-induced vascular proliferation and platelet activation are enhanced in mice that are genetically deficient in the PGI2 receptor
	mice lacking the PGI2 receptor have a ecreased susceptibility to renovascular hypertension