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FLASH GENE
Symbol PTGIR contributors: mct/shn - updated : 12-07-2012
HGNC name prostaglandin I2 (prostacyclin) receptor (IP)
HGNC id 9602
Location 19q13.32      Physical location : 47.123.725 - 47.128.354
Synonym name
  • PGI receptor
  • PGI2 receptor
  • prostacyclin receptor
  • prostanoid IP receptor
  • Synonym symbol(s) IP, PRIPR, MGC102830, HIP
    DNA
    TYPE functioning gene
    STRUCTURE 4.63 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - D19S219 - D19S412 - PTGIR - D19S606 - D19S902 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 2103 - 386 - 2006 16527812
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   lowly Homo sapiens
    Digestiveliver   highly Homo sapiens
    Respiratorylung   highly Homo sapiens
    Urinarykidney   highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal lowly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane segments (7TM) receptor
  • a 22-AAs putative RAB11 binding domain (RBD) within the C-terminal tail, proximal to the transmembrane 7 (TM7) domain , that is both necessary and sufficient to mediate interaction with RAB11A
  • HOMOLOGY
    interspecies ortholog to Ptgir, Mus musculus
    ortholog to Ptgir, Rattus norvegicus
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • an antithrombotic agent in vivo and provide evidence for its role as a mediator of inflammation and pain
  • receptor for prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, eliciting a potent vasodilation and inhibition of platelet aggregation through binding to this receptor
  • plays a central role in hemostasis, acting as a potent inhibitor of platelet activation and as an endothelium-derived vasodilator
  • plays a critical role in regulating the release of renin and consequently renovascular hypertension in vivo
  • plays critical roles in atheroprevention and cardioprotection
  • play an important role in preimplantation embryo development and mediate the embryo response to exogenous PGI(2)
  • PTGIR /prostaglandin I(2)system is essential forEndothelial progenitor cells to accomplish their function and plays a critical role in the regulation of vascular remodeling
  • undergoes agonist-induced internalization and subsequent recyclization in slowly recycling endosomes involving its direct physical interaction with RAB11A
  • PTGIR- pathway suppresses cardiac fibrosis, at least partly, by inducing CREB
  • undergoes agonist-dependent trafficking involving a direct interaction with RAB11A GTPase
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • delta subunit of cGMP phosphodiesterase 6, PDE6D
  • RAB11A
  • PDZK1
  • cell & other
    REGULATION
    Phosphorylated by protein kinase c, PKC
    Other transcriptional regulation in megakaryocytic and endothelial cells, through Sp1, SPI1 and POU2F1, critical factors involved in its basal regulation
    post-translationally modified by ubiquitination
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • disruption of the prostacyclin receptor gene in mice leads to increased susceptibility to thrombosis and reduced levels in inflammatory and pain responses
  • injury-induced vascular proliferation and platelet activation are enhanced in mice that are genetically deficient in the PGI2 receptor
  • mice lacking the PGI2 receptor have a ecreased susceptibility to renovascular hypertension