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FLASH GENE
Symbol PTGIR contributors: mct/shn - updated : 12-07-2012
HGNC name prostaglandin I2 (prostacyclin) receptor (IP)
HGNC id 9602
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor
  • a 22-AAs putative RAB11 binding domain (RBD) within the C-terminal tail, proximal to the transmembrane 7 (TM7) domain , that is both necessary and sufficient to mediate interaction with RAB11A
    • HOMOLOGY
    interspecies ortholog to Ptgir, Mus musculus
    ortholog to Ptgir, Rattus norvegicus
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
    • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • an antithrombotic agent in vivo and provide evidence for its role as a mediator of inflammation and pain
  • receptor for prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, eliciting a potent vasodilation and inhibition of platelet aggregation through binding to this receptor
  • plays a central role in hemostasis, acting as a potent inhibitor of platelet activation and as an endothelium-derived vasodilator
  • plays a critical role in regulating the release of renin and consequently renovascular hypertension in vivo
  • plays critical roles in atheroprevention and cardioprotection
  • play an important role in preimplantation embryo development and mediate the embryo response to exogenous PGI(2)
  • PTGIR /prostaglandin I(2)system is essential forEndothelial progenitor cells to accomplish their function and plays a critical role in the regulation of vascular remodeling
  • undergoes agonist-induced internalization and subsequent recyclization in slowly recycling endosomes involving its direct physical interaction with RAB11A
  • PTGIR- pathway suppresses cardiac fibrosis, at least partly, by inducing CREB
  • undergoes agonist-dependent trafficking involving a direct interaction with RAB11A GTPase
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • delta subunit of cGMP phosphodiesterase 6, PDE6D
  • RAB11A
  • PDZK1
    • cell & other
    REGULATION
    Phosphorylated by protein kinase c, PKC
    Other transcriptional regulation in megakaryocytic and endothelial cells, through Sp1, SPI1 and POU2F1, critical factors involved in its basal regulation
    post-translationally modified by ubiquitination
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • disruption of the prostacyclin receptor gene in mice leads to increased susceptibility to thrombosis and reduced levels in inflammatory and pain responses
  • injury-induced vascular proliferation and platelet activation are enhanced in mice that are genetically deficient in the PGI2 receptor
  • mice lacking the PGI2 receptor have a ecreased susceptibility to renovascular hypertension