basic FUNCTION
| an antithrombotic agent in vivo and provide evidence for its role as a mediator of inflammation and pain |
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receptor for prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, eliciting a potent vasodilation and inhibition of platelet aggregation through binding to this receptor |
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plays a central role in hemostasis, acting as a potent inhibitor of platelet activation and as an endothelium-derived vasodilator |
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plays a critical role in regulating the release of renin and consequently renovascular hypertension in vivo |
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plays critical roles in atheroprevention and cardioprotection |
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play an important role in preimplantation embryo development and mediate the embryo response to exogenous PGI(2) |
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PTGIR /prostaglandin I(2)system is essential forEndothelial progenitor cells to accomplish their function and plays a critical role in the regulation of vascular remodeling |
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undergoes agonist-induced internalization and subsequent recyclization in slowly recycling endosomes involving its direct physical interaction with RAB11A |
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PTGIR- pathway suppresses cardiac fibrosis, at least partly, by inducing CREB |
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undergoes agonist-dependent trafficking involving a direct interaction with RAB11A GTPase |