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FLASH GENE
Symbol PTGIR contributors: mct/shn - updated : 12-07-2012
HGNC name prostaglandin I2 (prostacyclin) receptor (IP)
HGNC id 9602
DNA
TYPE functioning gene
STRUCTURE 4.63 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map cen - D19S219 - D19S412 - PTGIR - D19S606 - D19S902 - qter
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 2103 - 386 - 2006 16527812
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   lowly Homo sapiens
Digestiveliver   highly Homo sapiens
Respiratorylung   highly Homo sapiens
Urinarykidney   highly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal lowly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor
  • a 22-AAs putative RAB11 binding domain (RBD) within the C-terminal tail, proximal to the transmembrane 7 (TM7) domain , that is both necessary and sufficient to mediate interaction with RAB11A
  • HOMOLOGY
    interspecies ortholog to Ptgir, Mus musculus
    ortholog to Ptgir, Rattus norvegicus
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • an antithrombotic agent in vivo and provide evidence for its role as a mediator of inflammation and pain
  • receptor for prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, eliciting a potent vasodilation and inhibition of platelet aggregation through binding to this receptor
  • plays a central role in hemostasis, acting as a potent inhibitor of platelet activation and as an endothelium-derived vasodilator
  • plays a critical role in regulating the release of renin and consequently renovascular hypertension in vivo
  • plays critical roles in atheroprevention and cardioprotection
  • play an important role in preimplantation embryo development and mediate the embryo response to exogenous PGI(2)
  • PTGIR /prostaglandin I(2)system is essential forEndothelial progenitor cells to accomplish their function and plays a critical role in the regulation of vascular remodeling
  • undergoes agonist-induced internalization and subsequent recyclization in slowly recycling endosomes involving its direct physical interaction with RAB11A
  • PTGIR- pathway suppresses cardiac fibrosis, at least partly, by inducing CREB
  • undergoes agonist-dependent trafficking involving a direct interaction with RAB11A GTPase
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • delta subunit of cGMP phosphodiesterase 6, PDE6D
  • RAB11A
  • PDZK1
  • cell & other
    REGULATION
    Phosphorylated by protein kinase c, PKC
    Other transcriptional regulation in megakaryocytic and endothelial cells, through Sp1, SPI1 and POU2F1, critical factors involved in its basal regulation
    post-translationally modified by ubiquitination
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • disruption of the prostacyclin receptor gene in mice leads to increased susceptibility to thrombosis and reduced levels in inflammatory and pain responses
  • injury-induced vascular proliferation and platelet activation are enhanced in mice that are genetically deficient in the PGI2 receptor
  • mice lacking the PGI2 receptor have a ecreased susceptibility to renovascular hypertension