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FLASH GENE

Symbol

GIMAP5

contributors: mct - updated : 30-05-2023

HGNC name	GTPase, IMAP family member 5
HGNC id	18005

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

NCPH2

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   resulted in a major increase in the number of apoptotic cells constitutional       loss of function impair immunological tolerance and lymphocyte survival and ultimately drive the development of CD4(+) T cell-mediated early-onset colitis

Susceptibility

to systemic lupus erythematosus

Variant & Polymorphism repeat	common polyadenylation polymorphism increasing risk to systemic lupus erythematosus

Candidate gene
Marker	could be a potential biomarker for the diagnosis and prognosis of lung cancer
Therapy target

ANIMAL & CELL MODELS

in mice and in rats, the loss of functional GTPase of the immune associated nucleotide binding protein 5 (Gimap5) causes peripheral T lymphopenia due to spontaneous death of T cells