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FLASH GENE

Symbol

GIMAP5

contributors: mct - updated : 04-05-2011

HGNC name	GTPase, IMAP family member 5
HGNC id	18005

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal GTP binding motif
	central coiled-coil domain responsible for centrosomal anchoring and resistance toward death
	five motifs conserved in GTP-binding proteins
	one hydrophobic segments at the C terminus predicted to form transmembrane (TM) spanning helices

HOMOLOGY

interspecies	homolog to murine Ian4
	ortholog to murine Imap38

Homologene

FAMILY

immune-associated nucleotide (Ian)-related gene family

CATEGORY

signaling

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,outer
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,lysosome
text	localization at the endoplasmic reticulum
	found to be located in a membraneous compartment/s which was also detected by established markers of lysosomes

basic FUNCTION	putative GTP-binding activity, may be playing a role in the control of cell death/survival
	regulates T lymphocyte survival by mechanisms that operate upstream of mitochondria
	important regulator of calcium response in T lymphocytes
	role for GIMAPs in the late stages of lymphocyte development and in lymphocyte maintenance

CELLULAR PROCESS	cell life, antiapoptosis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interact with members of the BCL2 family and regulate apoptosis
	CISD2 interact with GIMAP5 on the mitochondrial and ER membranes and thereby modulate mitochondrial Ca(2+) uptake associated with the maintenance of intracellular Ca(2+) homeostasis in adipocytes

cell & other

REGULATION

activated by	by NOTCH1 in T-ALL cell lines (NOTCH1 signalling protects T-ALL cells from apoptosis by upregulating the expression of GIMAP5)

induced by

BCR/ABL

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   resulted in a major increase in the number of apoptotic cells

Susceptibility

to systemic lupus erythematosus

Variant & Polymorphism repeat	common polyadenylation polymorphism increasing risk to systemic lupus erythematosus

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS