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FLASH GENE
Symbol GIMAP5 contributors: mct - updated : 04-05-2011
HGNC name GTPase, IMAP family member 5
HGNC id 18005
DNA
TYPE anonymous DNA segment
SPECIAL FEATURE component of a cluster
STRUCTURE 6.29 kb     3 Exon(s)
motif repetitive sequence   other
text structure two consecutive polyA signals and one SNP
MAPPING cloned Y linked Y status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 1861 - 307 - 2007 17369194
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx   highly
Endocrineadrenal gland   highly
Lymphoid/Immunespleen   highly
Respiratorylung    
cell lineage hemapoietic cells, predominantly
cell lines
fluid/secretion
at STAGE
physiological period embryo
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal GTP binding motif
  • central coiled-coil domain responsible for centrosomal anchoring and resistance toward death
  • five motifs conserved in GTP-binding proteins
  • one hydrophobic segments at the C terminus predicted to form transmembrane (TM) spanning helices
  • HOMOLOGY
    interspecies homolog to murine Ian4
    ortholog to murine Imap38
    Homologene
    FAMILY immune-associated nucleotide (Ian)-related gene family
    CATEGORY signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,lysosome
    text
  • localization at the endoplasmic reticulum
  • found to be located in a membraneous compartment/s which was also detected by established markers of lysosomes
  • basic FUNCTION
  • putative GTP-binding activity, may be playing a role in the control of cell death/survival
  • regulates T lymphocyte survival by mechanisms that operate upstream of mitochondria
  • important regulator of calcium response in T lymphocytes
  • role for GIMAPs in the late stages of lymphocyte development and in lymphocyte maintenance
  • CELLULAR PROCESS cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with members of the BCL2 family and regulate apoptosis
  • CISD2 interact with GIMAP5 on the mitochondrial and ER membranes and thereby modulate mitochondrial Ca(2+) uptake associated with the maintenance of intracellular Ca(2+) homeostasis in adipocytes
  • cell & other
    REGULATION
    activated by by NOTCH1 in T-ALL cell lines (NOTCH1 signalling protects T-ALL cells from apoptosis by upregulating the expression of GIMAP5)
    induced by BCR/ABL
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    resulted in a major increase in the number of apoptotic cells
    Susceptibility to systemic lupus erythematosus
    Variant & Polymorphism repeat common polyadenylation polymorphism increasing risk to systemic lupus erythematosus
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS