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FLASH GENE

Symbol

GIMAP5

contributors: mct - updated : 30-05-2023

HGNC name	GTPase, IMAP family member 5
HGNC id	18005

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_018384 3 - 1804 NP_060854 - 307 - 2007 17369194

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver vessel     highly Homo sapiens   pharynx       highly Lymphoid/Immune spleen       highly Respiratory lung

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular smooth vessel     Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Cardiovascular endothelial cell Homo sapiens Lymphoid/Immune lymphocyte Homo sapiens

cell lineage	hemapoietic cells, predominantly
cell lines
fluid/secretion

at STAGE

physiological period

embryo

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal GTP binding motif
	central coiled-coil domain responsible for centrosomal anchoring and resistance toward death
	five motifs conserved in GTP-binding proteins
	one hydrophobic segments at the C terminus predicted to form transmembrane (TM) spanning helices

HOMOLOGY

interspecies	homolog to murine Ian4
	ortholog to murine Imap38

Homologene

FAMILY

immune-associated nucleotide (Ian)-related gene family

CATEGORY

signaling

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,outer
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,lysosome
text	localization at the endoplasmic reticulum
	found to be located in a membraneous compartment/s which was also detected by established markers of lysosomes

basic FUNCTION	putative GTP-binding activity, may be playing a role in the control of cell death/survival
	regulates T lymphocyte survival by mechanisms that operate upstream of mitochondria
	important regulator of calcium response in T lymphocytes
	role for GIMAPs in the late stages of lymphocyte development and in lymphocyte maintenance
	pro-survival function of GIMAP5 in T-lymphocytes may be linked to its requirement to facilitate microtubule-dependent mitochondrial buffering of Ca2+ following capacitative entry
	GIMAP5 regulates the lysosomal Ca2+ compartment in T lymphocytes
	expression of GIMAP5 is lymphocyte-restricted, , and likely its control of GSK3B is an important checkpoint in lymphocyte proliferation
	GIMAP5 is a critical regulator of liver endothelial cell homeostasis and, when absent, produces portal hypertension

CELLULAR PROCESS	cell life, antiapoptosis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interact with members of the BCL2 family and regulate apoptosis
	CISD2 interact with GIMAP5 on the mitochondrial and ER membranes and thereby modulate mitochondrial Ca(2+) uptake associated with the maintenance of intracellular Ca(2+) homeostasis in adipocytes
	GIMAP5 is essential for the inactivation of GSK3B following T cell activation
	GIMAP5 promoted the transport of M6PR from the cytoplasm to the cell membrane, thereby inhibiting the enhancement of EMT-related PADI4
	GIMAP5 could inhibit the growth of lung cancer by interacting with M6PR
	GIMAP5 promotes the degradation of Respiratory syncytial virus (RSV) and its receptor through interacting with M6PR

cell & other

REGULATION

activated by	by NOTCH1 in T-ALL cell lines (NOTCH1 signalling protects T-ALL cells from apoptosis by upregulating the expression of GIMAP5)

induced by

BCR/ABL

ASSOCIATED DISORDERS

corresponding disease(s)

NCPH2

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   resulted in a major increase in the number of apoptotic cells constitutional       loss of function impair immunological tolerance and lymphocyte survival and ultimately drive the development of CD4(+) T cell-mediated early-onset colitis

Susceptibility

to systemic lupus erythematosus

Variant & Polymorphism repeat	common polyadenylation polymorphism increasing risk to systemic lupus erythematosus

Candidate gene
Marker	could be a potential biomarker for the diagnosis and prognosis of lung cancer
Therapy target

ANIMAL & CELL MODELS

in mice and in rats, the loss of functional GTPase of the immune associated nucleotide binding protein 5 (Gimap5) causes peripheral T lymphopenia due to spontaneous death of T cells