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FLASH GENE
Symbol SUB1 contributors: mlc - updated : 03-12-2007
HGNC name SUB1 homolog (S. cerevisiae)
HGNC id 19985
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,chromatin/chromosome
text associated with the chromatin throughout the stages of cell cycle and is broadly distributed on the mitotic chromosome arms in a punctate manner except for the centromere
basic FUNCTION
  • may be involved in stabilizing the multiprotein transcription complex
  • mediates functional interactions between upstream activators and the general transcriptional machinery
  • playing a physiological role as a chromatin-compacting protein, inducing chromatin condensation
  • acting as a general coactivator for activator-dependent transcription, the activity of which is regulated negatively by phosphorylation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with CSTF2
  • unique activator of TP53 function
  • acetylated specifically by another coactivator, EP300
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS