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FLASH GENE
Symbol SUB1 contributors: mlc - updated : 03-12-2007
HGNC name SUB1 homolog (S. cerevisiae)
HGNC id 19985
Location 5p13.3      Physical location : 32.585.604 - 32.604.185
Synonym name
  • activated RNA polymerase II transcription cofactor 4
  • positive cofactor 4
    • Synonym symbol(s) MGC102747, P15, PC4, p14
    DNA
    TYPE functioning gene
    STRUCTURE 16.00 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1336 - 127 - Olsen (2006)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly
     salivary gland   highly
    Hearing/Equilibriumear   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    text associated with the chromatin throughout the stages of cell cycle and is broadly distributed on the mitotic chromosome arms in a punctate manner except for the centromere
    basic FUNCTION
  • may be involved in stabilizing the multiprotein transcription complex
  • mediates functional interactions between upstream activators and the general transcriptional machinery
  • playing a physiological role as a chromatin-compacting protein, inducing chromatin condensation
  • acting as a general coactivator for activator-dependent transcription, the activity of which is regulated negatively by phosphorylation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with CSTF2
  • unique activator of TP53 function
  • acetylated specifically by another coactivator, EP300
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS