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FLASH GENE
Symbol SUB1 contributors: mlc - updated : 03-12-2007
HGNC name SUB1 homolog (S. cerevisiae)
HGNC id 19985
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1336 - 127 - Olsen (2006)
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue  highly
 salivary gland   highly
Hearing/Equilibriumear   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,chromatin/chromosome
text associated with the chromatin throughout the stages of cell cycle and is broadly distributed on the mitotic chromosome arms in a punctate manner except for the centromere
basic FUNCTION
  • may be involved in stabilizing the multiprotein transcription complex
  • mediates functional interactions between upstream activators and the general transcriptional machinery
  • playing a physiological role as a chromatin-compacting protein, inducing chromatin condensation
  • acting as a general coactivator for activator-dependent transcription, the activity of which is regulated negatively by phosphorylation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with CSTF2
  • unique activator of TP53 function
  • acetylated specifically by another coactivator, EP300
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS