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FLASH GENE
Symbol SUB1 contributors: mlc - updated : 03-12-2007
HGNC name SUB1 homolog (S. cerevisiae)
HGNC id 19985
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue  highly
 salivary gland   highly
Hearing/Equilibriumear   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,chromatin/chromosome
text associated with the chromatin throughout the stages of cell cycle and is broadly distributed on the mitotic chromosome arms in a punctate manner except for the centromere
basic FUNCTION
  • may be involved in stabilizing the multiprotein transcription complex
  • mediates functional interactions between upstream activators and the general transcriptional machinery
  • playing a physiological role as a chromatin-compacting protein, inducing chromatin condensation
  • acting as a general coactivator for activator-dependent transcription, the activity of which is regulated negatively by phosphorylation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with CSTF2
  • unique activator of TP53 function
  • acetylated specifically by another coactivator, EP300
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS