Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol NFKBIE contributors: npt/ - updated : 04-01-2006
HGNC name nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
HGNC id 7799
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six ankyrin repeats
  • two conserved serines
    • conjugated PhosphoP
    HOMOLOGY
    interspecies ortholog to murine Nfkbie
    Homologene
    FAMILY
  • NF-Kappa B inhibitor family
    • CATEGORY regulatory , transcription factor , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • inhibitor of NFKB that tightly regulates NFKB activation by complexing and trapping it the cytoplasm
  • inhibiting NFkappaB by preventing its translocation to the nucleus
    • CELLULAR PROCESS nucleotide, transcription
    protein, post translation, targeting
    PHYSIOLOGICAL PROCESS immunity/defense , inflammation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to p52 subunit of RELA-CRel-NFKB complexes
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS