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FLASH GENE
Symbol NFKBIE contributors: npt/ - updated : 04-01-2006
HGNC name nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
HGNC id 7799
Location 6p21.1      Physical location : 44.225.902 - 44.233.525
Synonym name
  • inhibitor of Kappa light chain enhancer in B cells, epsilon
  • I-kappa-B-epsilon
    • Synonym symbol(s) EVI132, IKBE, NF-kappa-BIE, IkB-epsilon
    DNA
    TYPE functioning gene
    STRUCTURE 7.62 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2581 52.7 500 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Digestiveliver    
    Endocrinepancreas   moderately
    Lymphoid/Immunespleen   highly
    Nervousbrain   moderately
    Reproductivemale systemtestis  highly
     male systemprostate   
    Respiratorylung   highly
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticgranulocyte
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • six ankyrin repeats
  • two conserved serines
    • conjugated PhosphoP
    HOMOLOGY
    interspecies ortholog to murine Nfkbie
    Homologene
    FAMILY
  • NF-Kappa B inhibitor family
    • CATEGORY regulatory , transcription factor , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • inhibitor of NFKB that tightly regulates NFKB activation by complexing and trapping it the cytoplasm
  • inhibiting NFkappaB by preventing its translocation to the nucleus
    • CELLULAR PROCESS nucleotide, transcription
    protein, post translation, targeting
    PHYSIOLOGICAL PROCESS immunity/defense , inflammation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to p52 subunit of RELA-CRel-NFKB complexes
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS