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FLASH GENE
Symbol NFKBIE contributors: npt/ - updated : 04-01-2006
HGNC name nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
HGNC id 7799
DNA
TYPE functioning gene
STRUCTURE 7.62 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 2581 52.7 500 - -
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Digestiveliver    
Endocrinepancreas   moderately
Lymphoid/Immunespleen   highly
Nervousbrain   moderately
Reproductivemale systemtestis  highly
 male systemprostate   
Respiratorylung   highly
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticgranulocyte
Lymphoid/Immunemacrophage
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six ankyrin repeats
  • two conserved serines
  • conjugated PhosphoP
    HOMOLOGY
    interspecies ortholog to murine Nfkbie
    Homologene
    FAMILY
  • NF-Kappa B inhibitor family
  • CATEGORY regulatory , transcription factor , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • inhibitor of NFKB that tightly regulates NFKB activation by complexing and trapping it the cytoplasm
  • inhibiting NFkappaB by preventing its translocation to the nucleus
  • CELLULAR PROCESS nucleotide, transcription
    protein, post translation, targeting
    PHYSIOLOGICAL PROCESS immunity/defense , inflammation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to p52 subunit of RELA-CRel-NFKB complexes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS