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FLASH GENE

Symbol

NFKBIE

contributors: npt/ - updated : 04-01-2006

HGNC name	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
HGNC id	7799

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	7.62 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 6 - 2581 isoform 1 52.7 500 - -

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       moderately Digestive liver         Endocrine pancreas       moderately Lymphoid/Immune spleen       highly Nervous brain       moderately Reproductive male system testis     highly   male system prostate       Respiratory lung       highly Urinary kidney       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic granulocyte Lymphoid/Immune macrophage

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	six ankyrin repeats
	two conserved serines

conjugated

PhosphoP

HOMOLOGY

interspecies

ortholog to murine Nfkbie

Homologene

FAMILY

NF-Kappa B inhibitor family

CATEGORY

regulatory , transcription factor , signaling

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	inhibitor of NFKB that tightly regulates NFKB activation by complexing and trapping it the cytoplasm
	inhibiting NFkappaB by preventing its translocation to the nucleus

CELLULAR PROCESS	nucleotide, transcription
	protein, post translation, targeting

PHYSIOLOGICAL PROCESS

immunity/defense , inflammation

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

binding to p52 subunit of RELA-CRel-NFKB complexes

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS