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FLASH GENE
Symbol NFKBIE contributors: npt/ - updated : 04-01-2006
HGNC name nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
HGNC id 7799
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Digestiveliver    
Endocrinepancreas   moderately
Lymphoid/Immunespleen   highly
Nervousbrain   moderately
Reproductivemale systemtestis  highly
 male systemprostate   
Respiratorylung   highly
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticgranulocyte
Lymphoid/Immunemacrophage
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six ankyrin repeats
  • two conserved serines
    • conjugated PhosphoP
    HOMOLOGY
    interspecies ortholog to murine Nfkbie
    Homologene
    FAMILY
  • NF-Kappa B inhibitor family
    • CATEGORY regulatory , transcription factor , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • inhibitor of NFKB that tightly regulates NFKB activation by complexing and trapping it the cytoplasm
  • inhibiting NFkappaB by preventing its translocation to the nucleus
    • CELLULAR PROCESS nucleotide, transcription
    protein, post translation, targeting
    PHYSIOLOGICAL PROCESS immunity/defense , inflammation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to p52 subunit of RELA-CRel-NFKB complexes
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS