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FLASH GENE
Symbol KIF13A contributors: mct - updated : 30-05-2023
HGNC name kinesin family member 13A
HGNC id 14566
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminus with motor and stalk domain
  • consensus ATP/GTP binding site
  • a forkhead-associated (FHA) domain of KIF13A
  • NC-CC1 domains
  • variable C terminal domain
    • HOMOLOGY
    interspecies homolog to kif13a mannose 6 phosphate receptor transporter
    ortholog to Drosophila kinesin 73
    Homologene
    FAMILY
  • kinesin-3 family
    • CATEGORY protooncogene , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus
    basic FUNCTION
  • involved in the transport of specific synaptic vesicles
  • contributing to malignant progression of retinoblastoma
  • role for this molecular motor in anxiety control
  • KIF13A associates with recycling endosome tubules and controls their morphogenesis
  • KIF13A plays an important role in the transport of influenza A vRNPs, a crucial step for viral assembly
  • KIF13A motors are tuned at a single-molecule level to function as weak dimers on the cellular cargo
  • implicated in several processes in many cell types, including cargo transport, recycling endosomal tubule biogenesis, cell polarity, migration and cytokinesis
  • is a key regulator of recycling endosome dynamics
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cell to cell transport
    PATHWAY
    metabolism
    signaling
    a component
  • RAB22A forms a complex with BLOC1S1, BLOC1S2 and the kinesin-3 family motor KIF13A on endosomes
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BLOC1S1 coordinates the kinesin KIF13A-dependent pulling of endosomal tubules along microtubules to the ANXA2/actin-dependent stabilization and detachment of recycling tubules
  • MTOR regulates M6PR transport and T-cell vulnerability to regulatory T cells controlling kinesin KIF13A
  • KIF13A and KIF13B are novel RAB10-interacting proteins, and RAB10 regulates tubular endosome formation through KIF13A and KIF13B motors
  • RAB22A plays an unusual role by binding to NC-CC1 domains of KIF13A, relieving proline-mediated inhibition and facilitating motor dimerization
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    KIF13A-RET fusion in lung adenocarcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS