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FLASH GENE
Symbol KIF13A contributors: npt/ - updated : 17-12-2003
HGNC name kinesin family member 13A
HGNC id 14566
DNA
TYPE functioning gene
STRUCTURE 227.21 kb     38 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence cytosine-phosphate-guanine/HTF
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 5740 - 1749 - Jamain
lack of exon 37
- - 5110 - 1757 heart, skeletal muscle, fetal muscle Jamain
lack of exon 36
- - 4690 - 659 keart, skeletal muscle, fetal muscle Jamain
lack of exon36-37
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveintestinelarge intestinecolon  
Endocrinepancreas    
Nervousbrain   highly
Reproductivemale systemprostate   
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Muscularstriatumskeletal  
cell lineage
cell lines retinoblastoma cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text kidney, placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminus with motor and stalk domain
  • consensus ATP/GTP binding site
  • variable C terminal domain
  • HOMOLOGY
    interspecies homolog to kif13a mannose 6 phosphate receptor transporter
    ortholog to Drosophila kinesin 73
    Homologene
    FAMILY
  • kinesin-like protein family
  • CATEGORY protooncogene , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus
    basic FUNCTION
  • involved in the transport of specific synaptic vesicles
  • contributing to malignant progression of retinoblastoma
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cell to cell transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS