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FLASH GENE
Symbol KIF13A contributors: mct - updated : 30-05-2023
HGNC name kinesin family member 13A
HGNC id 14566
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveintestinelarge intestinecolon  
Endocrinepancreas    
Nervousbrain   highly
Reproductivemale systemprostate   
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Muscularstriatumskeletal  
cell lineage
cell lines retinoblastoma cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text kidney, placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminus with motor and stalk domain
  • consensus ATP/GTP binding site
  • a forkhead-associated (FHA) domain of KIF13A
  • NC-CC1 domains
  • variable C terminal domain
  • HOMOLOGY
    interspecies homolog to kif13a mannose 6 phosphate receptor transporter
    ortholog to Drosophila kinesin 73
    Homologene
    FAMILY
  • kinesin-3 family
  • CATEGORY protooncogene , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus
    basic FUNCTION
  • involved in the transport of specific synaptic vesicles
  • contributing to malignant progression of retinoblastoma
  • role for this molecular motor in anxiety control
  • KIF13A associates with recycling endosome tubules and controls their morphogenesis
  • KIF13A plays an important role in the transport of influenza A vRNPs, a crucial step for viral assembly
  • KIF13A motors are tuned at a single-molecule level to function as weak dimers on the cellular cargo
  • implicated in several processes in many cell types, including cargo transport, recycling endosomal tubule biogenesis, cell polarity, migration and cytokinesis
  • is a key regulator of recycling endosome dynamics
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cell to cell transport
    PATHWAY
    metabolism
    signaling
    a component
  • RAB22A forms a complex with BLOC1S1, BLOC1S2 and the kinesin-3 family motor KIF13A on endosomes
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BLOC1S1 coordinates the kinesin KIF13A-dependent pulling of endosomal tubules along microtubules to the ANXA2/actin-dependent stabilization and detachment of recycling tubules
  • MTOR regulates M6PR transport and T-cell vulnerability to regulatory T cells controlling kinesin KIF13A
  • KIF13A and KIF13B are novel RAB10-interacting proteins, and RAB10 regulates tubular endosome formation through KIF13A and KIF13B motors
  • RAB22A plays an unusual role by binding to NC-CC1 domains of KIF13A, relieving proline-mediated inhibition and facilitating motor dimerization
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    KIF13A-RET fusion in lung adenocarcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS