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FLASH GENE

Symbol

KIF13A

contributors: mct - updated : 30-05-2023

HGNC name	kinesin family member 13A
HGNC id	14566

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	6p22.3      Physical location : 17.760.584 - 17.987.799
Synonym name	homolog of mouse KIF13A mannose-6-phosphate receptor transporter
	kinesin-like protein RBKIN
Synonym symbol(s)	RBKIN, bA500C11.2, FLJ27232

DNA

TYPE	functioning gene
STRUCTURE	228.51 kb     38 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence

cytosine-phosphate-guanine/HTF

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed KIN13? - - 4690 - 659 keart, skeletal muscle, fetal muscle 2022 35122963 lack of exon36-37 NM_001105568 38 - 7153 NP_001099038 - 1749 - 2022 35122963 KIN13A2 lack of exon 37 NM_001105567 37 - 5863 NP_001099037 - 1757 heart, skeletal muscle, fetal muscle 2022 35122963 KIN13A1 lack of exon 36 NM_001105566 38 - 5902 NP_001099036 - 1770 - 2022 35122963 NM_022113 39 - 6007 NP_071396 - 1805 - 2022 35122963 NM_001243423 3 - 1342 NP_001230352 - 70 - 2022 35122963

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive intestine large intestine colon     Endocrine pancreas         Nervous brain       highly Reproductive male system prostate       Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Muscular striatum skeletal

cell lineage
cell lines	retinoblastoma cell lines
fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text	kidney, placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminus with motor and stalk domain
	consensus ATP/GTP binding site
	a forkhead-associated (FHA) domain of KIF13A
	NC-CC1 domains
	variable C terminal domain

HOMOLOGY

interspecies	homolog to kif13a mannose 6 phosphate receptor transporter
	ortholog to Drosophila kinesin 73

Homologene

FAMILY

kinesin-3 family

CATEGORY

protooncogene , transport

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,organelle,endosome
	intracellular,cytoplasm,cytosolic
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
	intracellular,nucleus

basic FUNCTION	involved in the transport of specific synaptic vesicles
	contributing to malignant progression of retinoblastoma
	role for this molecular motor in anxiety control
	KIF13A associates with recycling endosome tubules and controls their morphogenesis
	KIF13A plays an important role in the transport of influenza A vRNPs, a crucial step for viral assembly
	KIF13A motors are tuned at a single-molecule level to function as weak dimers on the cellular cargo
	implicated in several processes in many cell types, including cargo transport, recycling endosomal tubule biogenesis, cell polarity, migration and cytokinesis
	is a key regulator of recycling endosome dynamics

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cell to cell transport

PATHWAY

metabolism

signaling

a component

RAB22A forms a complex with BLOC1S1, BLOC1S2 and the kinesin-3 family motor KIF13A on endosomes

INTERACTION

DNA

RNA

small molecule

protein	BLOC1S1 coordinates the kinesin KIF13A-dependent pulling of endosomal tubules along microtubules to the ANXA2/actin-dependent stabilization and detachment of recycling tubules
	MTOR regulates M6PR transport and T-cell vulnerability to regulatory T cells controlling kinesin KIF13A
	KIF13A and KIF13B are novel RAB10-interacting proteins, and RAB10 regulates tubular endosome formation through KIF13A and KIF13B motors
	RAB22A plays an unusual role by binding to NC-CC1 domains of KIF13A, relieving proline-mediated inhibition and facilitating motor dimerization

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral fusion       KIF13A-RET fusion in lung adenocarcinoma

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS