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FLASH GENE
Symbol EIF5A2 contributors: mct - updated : 23-08-2010
HGNC name eukaryotic translation initiation factor 5A2
HGNC id 3301
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • hypusin containing protein
  • eIF5A domain
    • HOMOLOGY
    interspecies ortholog to eIF5A in vertebrates
    intraspecies paralog to eIF5A
    Homologene
    FAMILY
  • eIF-5A family
    • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    intracellular,nuclear envelope,pore
    basic FUNCTION
  • maintaining polyamine homeostasis at elevated levels during spermatogenesis
  • playing an important role in cell proliferation and survival
  • able to induce epithelial-mesenchymal transition (EMT), a key event in tumor invasion and metastasis, characterized by down-regulation of epithelial markers (E-cadherin and beta-catenin) and up-regulation of mesenchymal markers (fibronectin, N-cadherin, alpha-SMA, and vimentin)
  • plays an important role in hepatocellular carcinoma invasion and metastasis by inducing EMT, as well as stimulating cytoskeleton rearrangement through activation of RhoA and Rac1
    • CELLULAR PROCESS cell life, proliferation/growth
    cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism amine
    signaling
    cellular polyamine biosynthesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • substrate of XPO4 (EIF5A2 is amplified in tumors, and required for proliferation of XPO4-deficient tumor cells)
  • could also activate RhoA/Rac1 to stimulate the formation of stress fiber and lamellipodia
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    enhances cell motility and promotes tumor metastasis in hepatocellular carcinoma
    tumoral     --over  
    in ovarian and colorectal cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    targeting EIF5A hypusination by GC7 inhibitor or EIF5A2 by RNA interference (RNAi) may offer new therapeutic alternatives to hepatocellular carcinoma patients
    ANIMAL & CELL MODELS