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FLASH GENE
Symbol EIF5A2 contributors: mct - updated : 23-08-2010
HGNC name eukaryotic translation initiation factor 5A2
HGNC id 3301
RNA
TRANSCRIPTS type messenger
text two alternative 3' utr
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 5537 16.8 153 - 2003 14622290
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Reproductivemale systemtestis   
cell lineage
cell lines colorectal adenocarcinoma, ovarian carcinomas
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • hypusin containing protein
  • eIF5A domain
  • HOMOLOGY
    interspecies ortholog to eIF5A in vertebrates
    intraspecies paralog to eIF5A
    Homologene
    FAMILY
  • eIF-5A family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    intracellular,nuclear envelope,pore
    basic FUNCTION
  • maintaining polyamine homeostasis at elevated levels during spermatogenesis
  • playing an important role in cell proliferation and survival
  • able to induce epithelial-mesenchymal transition (EMT), a key event in tumor invasion and metastasis, characterized by down-regulation of epithelial markers (E-cadherin and beta-catenin) and up-regulation of mesenchymal markers (fibronectin, N-cadherin, alpha-SMA, and vimentin)
  • plays an important role in hepatocellular carcinoma invasion and metastasis by inducing EMT, as well as stimulating cytoskeleton rearrangement through activation of RhoA and Rac1
  • CELLULAR PROCESS cell life, proliferation/growth
    cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism amine
    signaling
    cellular polyamine biosynthesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • substrate of XPO4 (EIF5A2 is amplified in tumors, and required for proliferation of XPO4-deficient tumor cells)
  • could also activate RhoA/Rac1 to stimulate the formation of stress fiber and lamellipodia
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    enhances cell motility and promotes tumor metastasis in hepatocellular carcinoma
    tumoral     --over  
    in ovarian and colorectal cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    targeting EIF5A hypusination by GC7 inhibitor or EIF5A2 by RNA interference (RNAi) may offer new therapeutic alternatives to hepatocellular carcinoma patients
    ANIMAL & CELL MODELS