Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

EIF5A2

contributors: mct - updated : 23-08-2010

HGNC name	eukaryotic translation initiation factor 5A2
HGNC id	3301

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Reproductive male system testis

cell lineage
cell lines	colorectal adenocarcinoma, ovarian carcinomas
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	hypusin containing protein
	eIF5A domain

HOMOLOGY

interspecies

ortholog to eIF5A in vertebrates

intraspecies

paralog to eIF5A

Homologene

FAMILY

eIF-5A family

CATEGORY

RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus
	intracellular,nuclear envelope,pore

basic FUNCTION	maintaining polyamine homeostasis at elevated levels during spermatogenesis
	playing an important role in cell proliferation and survival
	able to induce epithelial-mesenchymal transition (EMT), a key event in tumor invasion and metastasis, characterized by down-regulation of epithelial markers (E-cadherin and beta-catenin) and up-regulation of mesenchymal markers (fibronectin, N-cadherin, alpha-SMA, and vimentin)
	plays an important role in hepatocellular carcinoma invasion and metastasis by inducing EMT, as well as stimulating cytoskeleton rearrangement through activation of RhoA and Rac1

CELLULAR PROCESS	cell life, proliferation/growth
	cell life, antiapoptosis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

amine

signaling

cellular polyamine biosynthesis

a component

INTERACTION

DNA

RNA

small molecule

protein	substrate of XPO4 (EIF5A2 is amplified in tumors, and required for proliferation of XPO4-deficient tumor cells)
	could also activate RhoA/Rac1 to stimulate the formation of stress fiber and lamellipodia

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   enhances cell motility and promotes tumor metastasis in hepatocellular carcinoma tumoral     --over   in ovarian and colorectal cancer

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer digestive liver targeting EIF5A hypusination by GC7 inhibitor or EIF5A2 by RNA interference (RNAi) may offer new therapeutic alternatives to hepatocellular carcinoma patients

ANIMAL & CELL MODELS