basic FUNCTION
| maintaining polyamine homeostasis at elevated levels during spermatogenesis |
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playing an important role in cell proliferation and survival |
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able to induce epithelial-mesenchymal transition (EMT), a key event in tumor invasion and metastasis, characterized by down-regulation of epithelial markers (E-cadherin and beta-catenin) and up-regulation of mesenchymal markers (fibronectin, N-cadherin, alpha-SMA, and vimentin) |
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plays an important role in hepatocellular carcinoma invasion and metastasis by inducing EMT, as well as stimulating cytoskeleton rearrangement through activation of RhoA and Rac1  |