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FLASH GENE

Symbol

BAG5

contributors: - updated : 04-09-2006

HGNC name	BCL2-associated athanogene 5
HGNC id	941

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	14q32.32      Physical location : 104.022.880 - 104.029.151
Synonym name	BAG-family molecular chaperone regulator-5
Synonym symbol(s)	KIAA0873

DNA

TYPE	functioning gene
STRUCTURE	5.00 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

Map	cen - D14S65 - D14S1019 - BDKRB2 - D14S267 - D14S78 - YY1 - D14S272 - BAG5 - CKB - IGH@ - qter
Authors	Gene Map (98)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - - 5006 55.9 488 - Kalia variant 2 - - 4847 51 447 - Kalia differing in the 5'UTR and coding region isoform b variant 3 - - 4840 51 447 - Kalia differing in the 5'UTR and coding region isoform b

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive pharynx       highly Endocrine neuroendocrine pituitary     highly Reproductive male system testis     highly Respiratory respiratory tract trachea     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	four BAG domains
	a C terminal BAG domain binding Hsc70/Hsp70

HOMOLOGY

Homologene

FAMILY

CATEGORY

chaperone/stress

SUBCELLULAR LOCALIZATION

basic FUNCTION	negative regulator of Hsp70 chaperone activity
	inhibiting parkin and enhancing dopaminergic neuron degeneration

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	binds to the atpase domain of HSP70/hsc chaperones
	binds PARK2

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS