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FLASH GENE

Symbol

IGH@

contributors: - updated : 22-07-2003

HGNC name	immunoglobulin heavy locus
HGNC id	5477

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	MGUS monoclonal gammopathy
Location	14q32.33      Physical location : -
Synonym symbol(s)	IGH, IGHDY1

DNA

TYPE

cluster

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

HOMOLOGY

Homologene

FAMILY

CATEGORY

immunity/defense

SUBCELLULAR LOCALIZATION

basic FUNCTION

antigen binding, immune response

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

MGUS

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   translocation     IgH translocations in multiple myeloma. Most frequent translocations involve cyclin D1(t(11;14)) and FGFR3(t(4;14))

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS