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FLASH GENE

Symbol

SERPINB13

contributors: mct - updated : 28-03-2011

HGNC name	serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 13
HGNC id	8944

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	11.90 kb     8 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Map	cen - SERPINB5 - SERPINB13 - SERPINB4 - SERPINB3 - qter
Authors	Nakashima (00)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_012397 8 - 3197 - 391 - 2000 11004515

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Skin/Tegument skin

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier/lining

cells

System Cell Pubmed Species Stage Rna symbol Skin/Tegument keratinocyte

cell lineage
cell lines
fluid/secretion	normal oral mucosa

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a serpin domain
	a reactive site loop near the C terminus

HOMOLOGY

intraspecies

homolog to SCCA1,SCCA2 serine proteinase inhibitor

Homologene

FAMILY

member of the serpin family, ovalbumin subgroup

CATEGORY

enzyme , regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	potent and selective inhibitor of the archetypal lysosomal cysteine proteinase cathepsin L (CTSL)
	playing a physiological role to protect epithelial cells from ectopic CTSL
	implicated in the keratinocytes UV-resistance
	serine proteinase inhibitor (serpin) with constitutive mRNA expression in histologically normal oral mucosa
	targets diverse mechanisms against tumor angiogenesis on which to base therapeutic strategies
	possible involvement in inflammatory processes or the regulation of endogenous or pathogen-derived proteinase activity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

RUNX1 binds the SERPINB13 promoter in chromatin to repress its transcription

cell & other

REGULATION

inhibited by

by UV light

repressed by

RUNX1 (RUNX1 repressed SERPINB13 resulting in increased cathepsin K enzymatic activity)

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in oral squamous cell carcinomas

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS