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FLASH GENE

Symbol

SAA1

contributors: - updated : 22-12-2005

HGNC name	serum amyloid A1
HGNC id	10513

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11p15.1-p14.3      Physical location : 18.287.807 - 18.291.521
Synonym symbol(s)	SAA, PIG4, TP53I4

DNA

TYPE	functioning gene
STRUCTURE	2.00 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	Binding site   HRE
text structure	glucocorticoid response element (GRE)

MAPPING

cloned

Y

linked

N

status

confirmed

Map	cen - LDHC - LDHA - SAA1 - SAA2 - SAA4 - SAA3P - TPH1 - D11S18 - KCNC1 - MYOD1 - pter
Text	see MYOD1

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

SAA family

CATEGORY

secretory

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION

acute phase reactant may be be involved in inflammatory response

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

inflammation

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

induced by

cytokine stimulation.

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

for juvenile chronic arthritis and renal amyloidosis in familial Mediterranean fever

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS