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FLASH GENE
Symbol LDHC contributors: mct - updated : 15-05-2020
HGNC name lactate dehydrogenase C
HGNC id 6544
Location 11p15.1      Physical location : 18.433.852 - 18.472.792
Synonym name L-lactate dehydrogenase C chain
Synonym symbol(s) LDH3, LDHX, MGC111073, CT32
EC.number 1.1.1.27
DNA
TYPE functioning gene
STRUCTURE 39.77 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 splicing 1318 - 332 - 2017 28351304
variant 1 contains an upstream start of transcription and an alternatively spliced exon 1
8 splicing 2035 - 332 - 2017 28351304
variant 2 contains a downstream start of transcription and an alternatively spliced exon 1
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  highly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivespermatozoa Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , tetramer
HOMOLOGY
interspecies ortholog to murine Ldh3
ortholog to rattus ldhc
Homologene
FAMILY
  • LDH/MDH superfamily
  • LDH family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus
    basic FUNCTION
  • catalyzing the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis
  • in addition to its role in glycolysis, LDHC is likely part of a complex involved in ATP homeostasis that is disrupted in sperm lacking LDHC
  • spermatozoa require LDHC for capacitation, motility, and fertilizing capacity
  • sperm without LDHC were still able to convert lactate to pyruvate as mediated by LDHA that is tightly bound to the fibrous sheath
  • expression levels of GAPDHS, PGK2 and LDHC in the spermatozoa were closely correlated with progressive sperm motility
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • LDHC is required for LDHA expression in the sperm, and this unique functional interaction between LDH family members supports lactate dehydrogenase activity in the sperm
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    escaping from transcriptional repression, resulting in significant expression levels in virtually all tumor types tested
    Susceptibility to type 1 diabetes
    Variant & Polymorphism other
  • association between the methylation status of CpG sites within the LDHC gene and the development of insulin autoantibodies in early childhood in children who are carriers of the highest type 1 diabetes risk genotype
  • Candidate gene
    Marker
  • serum and exosomal LDHC may be an effective indicator for the diagnosis, efficacy evaluation, and monitoring the recurrence of breast cancer (BC)
  • Therapy target
    SystemTypeDisorderPubmed
    reproductioncontraception 
    is the unique target for contraception in both males and females
    cancer  
    offers potential future for immunotherapy of different types of cancers
    ANIMAL & CELL MODELS