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FLASH GENE
Symbol TPH1 contributors: mct/npt - updated : 10-02-2009
HGNC name tryptophan hydroxylase 1
HGNC id 12008
Location 11p15.1      Physical location : 18.042.083 - 18.062.335
Synonym name
  • tryptophan hydroxylase 1 (tryptophan 5-monooxygenase)
  • tryptophan 5-monooxygenase
  • indoleacetic acid-5-hydroxylase
  • Synonym symbol(s) TRPH , TPH, DELGEF, MGC119994, TPRH
    EC.number 1.14.16.4
    DNA
    TYPE like-sequence
    STRUCTURE 19.77 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site
    text structure pter in binding site
    MAPPING cloned Y linked Y status confirmed
    Map pter - TH - D11S1 - D11S12 - HBB ,D11S30 - D11S20 - CALCA ,TPH1 - LDHA LDHA ,SAA2 ,D11S18 ,D11S21 ,D11S31 - cen
    Physical map
    OR7E14P 11p15.1 olfactory receptor, family 7, subfamily E, member 14 pseudogene RPS13 11p15.1 ribosomal protein S13 PIK3C2A 11p15.1 phosphoinositide-3-kinase, class 2, alpha polypeptide LOC91561 11p15.1 similar to ribosomal protein S2; 40S ribosomal protein S2 NUCB2 11p15.1-p14 nucleobindin 2 DKFZp686O24166 11p15.1 hypothetical protein DKFZp686O24166 KCNJ11 11p15.1 potassium inwardly-rectifying channel, subfamily J, member 11 ABCC8 11p15.1 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 LOC387757 11 LOC387757 USH1C 11p14.3 Usher syndrome 1C (autosomal recessive, severe) FLJ21290 11p15.1 hypothetical protein FLJ21290 OTOG 11p14.3 otogelin KCNC1 11p15.3 potassium voltage-gated channel, Shaw-related subfamily, member 1 MYOD1 11p15.1 myogenic factor 3 DELGEF 11p14.3 myogenic factor 3 TPH1 11p15.1-p14.3 tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) LOC113174 11p15.1 hypothetical protein BC012010 SAA3P 11p15.1-p14.3 serum amyloid A3 pseudogene MRGX3 11p15.1 G protein-coupled receptor MRGX3 MRGX4 11p15.1 G protein-coupled receptor MRGX4 SAA4 11p15.1-p14.3 serum amyloid A4, constitutive SAA2 11p15.1-p14.3 serum amyloid A2 FAM10A5 11p15.1 family with sequence similarity 10, member A5 SAA1 11p15.1-p14.3 serum amyloid A1 HPS5 11p14 Hermansky-Pudlak syndrome 5 GTF2H1 11p15.1-p14 general transcription factor IIH, polypeptide 1, 62kDa LDHA 11p15.1-p14.3 lactate dehydrogenase A LDHC 11p15.1-p14.3 lactate dehydrogenase C MGC23940 11p15.1 hypothetical protein MGC23940 TSG101 11p15.2-p15.1 tumor susceptibility gene 101 UEV3 11p15.1 ubiquitin-conjugating enzyme E2-like LOC390097 11 similar to CGI-64 protein FLJ39441 11p15.1 hypothetical protein FLJ39441 FLJ90119 11p15.1 hypothetical protein FLJ90119 FLJ37794 11p15.1 hypothetical protein FLJ37794 PTPN5 11p15.2-p15.1 protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched) LOC390098 11 similar to G protein-coupled receptor MRGX1 LOC390099 11 similar to G protein-coupled receptor SNSR2 MRGX1 11p15.1 G protein-coupled receptor MRGX1 LOC390100 11 similar to G protein-coupled receptor MRGX3 LOC390101 11 similar to G protein-coupled receptor SNSR1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 1335 51 444 - Nielsen (1992)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Reproductivefemale systemuterus   
    Respiratorylung    
    Visualeye    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • ACT domain
  • mono polymer heptamer
    HOMOLOGY
    Homologene
    FAMILY
  • biopterin-dependent aromatic amino acid hydroxylase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • catalyses the rate-limiting step in the biosynthesis of serotonin (Winge 2007)
  • catalyzing the biopterin-dependent monooxygenation of tryptophan to 5-hydroxytryptophan (5HT), which is subsequently decarboxylated to form the neurotransmitter serotonin
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • ferrous ion
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to shizophrenia (rs1800532)
  • to heroin addiction
  • Variant & Polymorphism other association of a specific TPH1 haplotype with heroin addiction (Nielsen 2008)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS