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FLASH GENE
Symbol LDHA contributors: - updated : 30-06-2006
HGNC name lactate dehydrogenase A
HGNC id 6535
Corresponding disease
LDHA myoglobinuria, exertional and/or excessive fatigability
Location 11p15.1-p14.3      Physical location : 18.415.935 - 18.429.765
Synonym name proliferation-inducing gene 19 protein
Synonym symbol(s) LDH-M, LDH1, PIG19
EC.number 1.1.1.27
DNA
TYPE functioning gene
STRUCTURE 13.00 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
Physical map
DKFZp686O24166 11p15.1 hypothetical protein DKFZp686O24166 KCNJ11 11p15.1 potassium inwardly-rectifying channel, subfamily J, member 11 ABCC8 11p15.1 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 LOC387757 11 LOC387757 USH1C 11p14.3 Usher syndrome 1C (autosomal recessive, severe) FLJ21290 11p15.1 hypothetical protein FLJ21290 OTOG 11p14.3 otogelin KCNC1 11p15.3 potassium voltage-gated channel, Shaw-related subfamily, member 1 MYOD1 11p15.1 myogenic factor 3 DELGEF 11p14.3 myogenic factor 3 TPH1 11p15.1-p14.3 tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) LOC113174 11p15.1 hypothetical protein BC012010 SAA3P 11p15.1-p14.3 serum amyloid A3 pseudogene MRGX3 11p15.1 G protein-coupled receptor MRGX3 MRGX4 11p15.1 G protein-coupled receptor MRGX4 SAA4 11p15.1-p14.3 serum amyloid A4, constitutive SAA2 11p15.1-p14.3 serum amyloid A2 FAM10A5 11p15.1 family with sequence similarity 10, member A5 SAA1 11p15.1-p14.3 serum amyloid A1 HPS5 11p14 Hermansky-Pudlak syndrome 5 GTF2H1 11p15.1-p14 general transcription factor IIH, polypeptide 1, 62kDa LDHA 11p15.1-p14.3 lactate dehydrogenase A LDHC 11p15.1-p14.3 lactate dehydrogenase C MGC23940 11p15.1 hypothetical protein MGC23940 TSG101 11p15.2-p15.1 tumor susceptibility gene 101 UEV3 11p15.1 ubiquitin-conjugating enzyme E2-like LOC390097 11 similar to CGI-64 protein FLJ39441 11p15.1 hypothetical protein FLJ39441 FLJ90119 11p15.1 hypothetical protein FLJ90119 FLJ37794 11p15.1 hypothetical protein FLJ37794 PTPN5 11p15.2-p15.1 protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched) LOC390098 11 similar to G protein-coupled receptor MRGX1 LOC390099 11 similar to G protein-coupled receptor SNSR2 MRGX1 11p15.1 G protein-coupled receptor MRGX1 LOC390100 11 similar to G protein-coupled receptor MRGX3 LOC390101 11 similar to G protein-coupled receptor SNSR1 MRGX2 11p15.1 G protein-coupled receptor MRGX2 HIP14L 11p15.1 G protein-coupled receptor MRGX2 CSRP3 11p15.1 cysteine and glycine-rich protein 3 (cardiac LIM protein) FLJ23311 11p15.1 FLJ23311 protein LOC390102 11 similar to Proliferating cell nuclear antigen (PCNA) (Cyclin)
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveesophagus   highly
 liver   highly
Nervousbrain   highly
Reproductivefemale systemuteruscervix highly
Visualeyeanterior segmentcornea  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal predominantly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , tetramer
HOMOLOGY
Homologene
FAMILY lactate dehydrogenase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • catalyzing the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis
  • oxidative stress induces not only poly-ubiquitination but also mono-ubiquitination of LDHA, which may be involved in its lysosomal degradation during unloading
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    anaerobic glycolysis, final step
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by a non-genomic pathway of estrogen action
    ASSOCIATED DISORDERS
    corresponding disease(s) LDHA
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS