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FLASH GENE
Symbol MAP4K2 contributors: mct - updated : 14-12-2013
HGNC name mitogen-activated protein kinase kinase kinase kinase 2
HGNC id 6864
Location 11q13      Physical location : 64.556.609 - 64.570.713
Synonym name
  • RAB8 interacting protein
  • germinal centre kinase (GC kinase)
  • B lymphocyte serine/threonine protein kinase
    • Synonym symbol(s) RAB8IP, BL44, GCK
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 14.00 kb     32 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Map cen - D11S1357 - SERPING1 - SUPT16H - CNTF - OSBP - MS4A1 - MS4A2 - GIF GIF - D11S1765 - AHNAK - CD5 - FTH1 - D11S1883 - MAP4K2 - D11S913 - qter
    Authors geneMap (98)
    regionally located located in the MEN1 critical region
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
     tonsils   highly
    cell lineage
    cell lines
    fluid/secretion moderately in blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a protein kinase domain
  • a CNH domain
    • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to rattus Map4k2 (93.8 pc)
    homolog to murine Map4k2 (93.9 pc)
    Homologene
    FAMILY
  • MAP (mitogen-activated-protein) kinase family
  • serine/threonine protein kinases family
  • STE20 subfamily
    • CATEGORY enzyme , immunity/defense , transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • enhancing MAP3K1 oligomerization, which may relieve amino-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation
  • may play a role in the regulation of vesicle targeting or fusion
  • acting as a serine/threonine protein kinase
  • acting as a small GTPase regulator
  • participating in B-cell differentiation
  • specifically activating MAP kinases
    • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS immunity/defense
    text
  • vesicular transport
    • PATHWAY
    metabolism
    signaling signal transduction
  • JNK cascade
    • a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • Mg2+
  • ATP
    • protein
  • interacting with TRAF2
  • interacting with MAP3K1
  • interacting with RAB8A
  • EWSR1 depletion results in alternative splicing changes of genes involved in DNA repair and genotoxic stress signaling, including ABL1, CHEK2, and MAP4K2
    • cell & other
    REGULATION
    activated by phosphorylation
    TNF-alpha
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS