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FLASH GENE
Symbol CD5 contributors: mct/pgu - updated : 20-08-2013
HGNC name CD5 molecule
HGNC id 1685
Location 11q12.2      Physical location : 60.869.929 - 60.895.321
Synonym name
  • CD5 antigen (p56-62)
  • cell differentiation antigen CD5 (p56-62),single chain, identified by monoclonal antibodies T1, UCHT2, T101, HH9, AMG4
  • lymphocyte antigen T1/Leu-1
  • T-cell surface glycoprotein CD5
  • Synonym symbol(s) LEU1, T1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE
    text head to tail orientation with CD6
    STRUCTURE 25.39 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    motif repetitive sequence   other
    text structure a (TC)n(CA)n microsatellite in the 5' region
    MAPPING cloned Y linked N status confirmed
    Physical map
    MS4A4A 11q12 membrane-spanning 4-domains, subfamily A, member 4 MS4A6E 11q12.1 membrane-spanning 4-domains, subfamily A, member 6E MS4A7 11q12.1 membrane-spanning 4-domains, subfamily A, member 7 NYD-SP21 11q12.2 testes development-related NYD-SP21 MS4A5 11q12 membrane-spanning 4-domains, subfamily A, member 5 MS4A1 11q12.2-q13.1 membrane-spanning 4-domains, subfamily A, member 1 MS4A12 11q12.1 membrane-spanning 4-domains, subfamily A, member 12 MGC39681 11q12.2 hypothetical protein MGC39681 MS4A8B 11q12.1 membrane-spanning 4-domains, subfamily A, member 8B MGC35295 11q12.2 hypothetical protein MGC35295 LOC341116 11q12.2 similar to Membrane-spanning 4-domains subfamily A member 10 MGC2574 11q12.2 hypothetical protein MGC2574 GPR44 11q12-q13.3 G protein-coupled receptor 44 LOC255714 11q12.2 similar to ZP1 precursor NMP200 11q12.2 nuclear matrix protein NMP200 related to splicing factor PRP19 MGC5508 11q12.2 hypothetical protein MGC5508 GBP 11q12.2 likely ortholog of rat GRP78-binding protein SLC15A3 11q13.1 solute carrier family 15, member 3 CD6 11q13 CD6 antigen CD5 11q12.2 CD5 antigen (p56-62) FLJ20847 11q12.3 hypothetical protein FLJ20847 PGA5 11q13 pepsinogen 5, group I (pepsinogen A) FLJ32009 11q12.3 hypothetical protein FLJ32009 DDB1 11q12-q13.1 damage-specific DNA binding protein 1, 127kDa DKFZP586B1621 11q12.3 DKFZP586B1621 protein MGC20446 11q12.3 hypothetical protein MGC20446 HSPC196 11q12.3 hypothetical protein HSPC196 MGC:13379 11q13.1 HSPC244 FLJ12529 11q12.3 pre-mRNA cleavage factor I, 59 kDa subunit FLJ20487 11q12.3 hypothetical protein FLJ20487 FLJ32771 11q12.3 IIIG9 protein SYT7 11q12-q13.1 synaptotagmin VII LOC390205 11 similar to leucine-rich repeat-containing 10; leucine-rich repeat protein; leucine-rich containing 10 RPLP0P2 11cen-q12 ribosomal protein, large, P0 pseudogene 2 C11orf11 11q13.1 chromosome 11 open reading frame 11 C11orf9 11q12-q13.1 chromosome 11 open reading frame 9 C11orf10 11q12-q13.1 chromosome 11 open reading frame 10 FEN1 11q13.1 flap structure-specific endonuclease 1 FADS1 11q12.2-q13.1 fatty acid desaturase 1 FADS2 11q12-q13.1 fatty acid desaturase 2
    RNA
    TRANSCRIPTS type messenger
    text two isoforms, using exon1A (protein expressed at the cell surface) or exon 1B (protein retained in the cytoplasm) (PMID: 18641338)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 3180 67 495 - 2013 23376399
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneB cell
    Lymphoid/ImmuneT cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three extracellular scavenger receptor cysteine-rich domains (SRCR, group B)
  • forming a rod-like structure with domain 1 distal from the cell surface and separated from domain 2 and 3 by an O-glycosylated peptide linker region
  • an ITIM motif
  • a pseudo ITAM region that may play a crucial role in RASGAP mediated TCR downregulation, through a mechanism that involves the inactivation of ERK
  • distal cytoplasmic domain of CD5, including Y463, plays a relevant role in the downmodulation of TCR signals in thymocytes via CBL
  • conjugated GlycoP , PhosphoP
    HOMOLOGY
    interspecies homolog to murine Cd5
    intraspecies paralog to CD6
    Homologene
    FAMILY
    CATEGORY antigen , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may be acting as a receptor in regulating T-cell proliferation
  • protecting circulating tumor-antigen specific CTL for tumor-mediated activation-induced cell death
  • immunotyrosine-based inhibition motif-bearing receptor that antagonizes the overt T cell receptor activation response by recruiting inhibitory intracellular mediators such as PTPN6, RASA1, or CBL
  • functions as a negative regulator of TCR signaling during thymocyte development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of transmembrane glycoprotein (TM1)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CD72
  • interacting with PTPN6 and opposing actiavtion mediated by the B cell receptor
  • CD5 expression is associated with NFATC1 activity (and mildly STAT3 activity), indicating that CD5 controls IL10 secretion
  • CBL is an ubiquitin ligase that physically associates with CD5
  • cell & other
    REGULATION
    Other down-regulated by selection of the alternative exon 1B
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    microsatellite instability in mantle cell lymphoma and B-cell chronic lymphocytic leukemia
    Susceptibility to secondary progressive multiple sclerosis
    Variant & Polymorphism other
  • polymorphism in the promoter is associated with increased susceptibility to B-cell chronic lymphocytic leukemia and mantle cell lymphoma
  • Candidate gene
  • may be involved in malignant phenotype of chronic lymphocytic leukemia, due to its phosphorylation
  • Marker
    Therapy target
    ANIMAL & CELL MODELS