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FLASH GENE
Symbol CNTF contributors: mct/shn - updated : 23-10-2018
HGNC name ciliary neurotrophic factor
HGNC id 2169
Location 11q12.1      Physical location : 58.390.145 - 58.393.203
Synonym symbol(s) HCNTF
DNA
TYPE functioning gene
STRUCTURE 3.06 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
Map cen - D11S1777 - D11S4202 - CNTF - D11S2363 - D11S4075 - qter
Physical map
LOC219952 11q12.1 similar to Olfactory receptor 6Q1 LOC387771 11 LOC387771 LOC219953 11q12.1 similar to seven transmembrane helix receptor LOC219954 11q12.1 similar to Olfactory receptor 9I1 OR9I2P 11q13.1 olfactory receptor, family 9, subfamily I, member 2 pseudogene LOC219956 11q12.1 similar to Olfactory receptor 9Q1 LOC219957 11q12.1 similar to seven transmembrane helix receptor LOC219958 11q12.1 similar to Olfactory receptor 1S2 LOC219959 11q12.1 similar to Olfactory receptor 1S1 LOC219960 11q12.1 similar to Olfactory receptor 10Q1 LOC387772 11 similar to seven transmembrane helix receptor LOC219964 11q12.1 similar to Olfactory receptor 10Q1 LOC390185 11 similar to Olfactory receptor 5B13 LOC390186 11 similar to Olfactory receptor 5B2 (OST073) LOC219965 11q12.1 similar to Olfactory receptor 5B17 LOC390187 11 similar to Olfactory receptor 5B13 LOC390188 11 similar to Olfactory receptor 5B17 LOC390189 11 similar to Olfactory receptor 5B13 LOC390190 11 similar to Olfactory receptor 5B2 (OST073) LOC390191 11 similar to Olfactory receptor 5B16 LOC219968 11q12.1 similar to olfactory receptor MOR202-4 LPXN 11cen-q12.3 leupaxin ZFP91-CNTF 11q12.2 zinc finger protein 91 homolog (mouse), ciliary neurotrophic factor transcription unit ZFP91 11q12 zinc finger protein 91 homolog (mouse) CNTF 11q12.2 ciliary neurotrophic factor GLYAT 11q12.3 glycine-N-acyltransferase BXMAS2-10 11q12.2 BXMAS2-10 MGC15937 11q12.2 similar to RIKEN cDNA 0610008P16 gene LOC387773 11 similar to MGC15937 protein
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 1914 - 200 - 1991 1883844
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node   highly
 thymus   highly
Nervousbraindiencephalonhypothalamus  
Reproductivemale systemtestis  highly
Respiratoryrespiratory tractlarynx  highly
Visualeyeretina   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentralwhite matter  
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousastrocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a conserved binding site on ciliary neurotrophic factor receptor (CNTFR)
  • a high-affinity site in the C terminus of CNTF that interacts with the sortilin beta-propeller domain
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to Cntf, Mus musculus
    ortholog to Cntf, Rattus norvegicus
    Homologene
    FAMILY
  • interleukin-6 family of cytokines
  • CATEGORY signaling neurotransmitter cytokine
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • involved in axon outgrowth in retinal ganglion cells and in the spinal cord
  • playing a protective role in the inflammed nervous system (for the myelin)
  • promoting inactivation of muscle Ca2+ channels via PKC
  • protective factor in demyelinating central nervous system disease
  • having a trophic effects on denervated skeletal muscle and being a regulator of muscular strength in aging
  • playing a potentiel role of protective factor against weight gain during hypercaloric diet
  • promotes gene expression, cell survival and differentiation in various types of peripheral and central neurons, glia and nonneural cells
  • having a a possible neuroprotective role in the optic nerve head
  • pluripotent neurocytokine acting both centrally and peripherally and, has shown promise as a potential anti-obesogenic therapy
  • potent axon growth-promoting factor for mature retinal ganglion cells
  • with LIF, LEP, IL6, participate to the complex control of the reproductive function by affecting the development and function of the hypothalamus-pituitary system at different ontogenic times and anatomical sites
  • neuroprotective via an increased function of glial glutamate transporters
  • may directly modulate POMC gene expression via the activation of receptors localized in the cell nucleus, providing a novel plausible mechanism of CNTF action in regulating energy homeostasis
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    text stimulates gene expression, cell survival or differentiation in a variety of neuronal cell types such as sensory, sympathetic, ciliary and motor neurons
    PATHWAY
    metabolism
    signaling
    a component quaternary cytokine receptor complex consisting of IL6ST, LIFR, the cytokine Ciliary Neurotrophic Factor (CNTF), and its alpha receptor (CNTFRA)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • Leukemia inhibitory factor, LIF, alpha CNTF receptor and gp130 (
  • apolipoprotein E, apoE (
  • TNFA (repressed by CTNF for myelin protection)
  • activating leptin-like pathways and reducing fat
  • CNTF, and related ligands targeting CNTFR{alpha}, binds to sortilin with high affinity
  • KPNA4 is an important regulator of CNTF-induced oligodendrocyte differentiation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in brain in the lateral corticospinal tract in SLA (modifier gene leading to early onset of ALS1 in patients with SOD1 mutation)
    constitutional     --low  
    decrease was found in preeclampsia as compared with normal pregnancy (circulating CNTF might be associated with physiological and abnormal insulin resistance during pregnancy)
    Susceptibility to higher body mass index in males in Europa, not in American people
    Variant & Polymorphism other
    Candidate gene
  • role in therapeutic strategy to alleviate obesity-associated diseases
  • therapeutic potential of CNTF for the clinical treatment of progressive neurodegenerative diseases involving glutamate overflow
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    CNTF induces regeneration of cone outer segments in a rat model of retinal degeneration