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FLASH GENE
Symbol MS4A1 contributors: - updated : 05-09-2007
HGNC name membrane-spanning 4-domains, subfamily A, member 1
HGNC id 7315
Corresponding disease
CVID5 common variable immunodeficiency 5
Location 11q12.2      Physical location : 60.223.281 - 60.238.224
Synonym name
  • B-lymphocyte cell-surface antigen B1
  • CD20 antigen
  • B-lymphocyte antigen CD20
  • membrane-spanning 4-domains, subfamily A, member 2
  • leukocyte surface antigen Leu-16
  • Synonym symbol(s) B1CD20, B1, Bp35, MS4A2, CD20, LEU-16, MGC3969, S7
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 14.94 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter (TATA box)
    MAPPING cloned Y linked Y status confirmed
    Map see SEA
    Physical map
    LOC390195 11 similar to Olfactory receptor 5AN1 LOC390196 11 similar to seven transmembrane helix receptor LOC219981 11q12.2 similar to Olfactory receptor 5A2 LOC219982 11q12.2 similar to Olfactory receptor 5A1 (OST181) LOC219983 11q12.2 similar to Olfactory receptor 4D6 LOC390197 11 similar to seven transmembrane helix receptor LOC390198 11 similar to seven transmembrane helix receptor LOC219986 11q12.2 similar to seven transmembrane helix receptor LOC390199 11 similar to Olfactory receptor 4D9 LOC390200 11 similar to olfactory receptor MOR239-1 OSBP 11q12.2 oxysterol binding protein FLJ36874 11q12.2 hypothetical protein FLJ36874 LOC390201 11 similar to seven transmembrane helix receptor LOC390202 11 similar to olfactory receptor GA_x6K02T2RE5P-2207258-2206302 STX3A 11q12.1 syntaxin 3A MRPL16 11q12-q13.1 mitochondrial ribosomal protein L16 GIF 11q12.2 gastric intrinsic factor (vitamin B synthesis) TCN1 11q11-q12 transcobalamin I (vitamin B12 binding protein, R binder family) LOC390203 11 similar to hypothetical protein FLJ13352 LOC255649 11q12.2 hypothetical LOC255649 FLJ36198 11q12.2 hypothetical protein FLJ36198 MS4A3 11q12 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) MS4A2 11q12.2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) MS4A6A 11q12.1 membrane-spanning 4-domains, subfamily A, member 6A LOC390204 11 similar to membrane-spanning 4-domains, subfamily A, member 4 isoform b; membrane-spanning 4-domains, subfamily A, member 4A; four-span transmembrane protein; Fc epsilon receptor beta subunit homolog MS4A4A 11q12 membrane-spanning 4-domains, subfamily A, member 4 MS4A6E 11q12.1 membrane-spanning 4-domains, subfamily A, member 6E MS4A7 11q12.1 membrane-spanning 4-domains, subfamily A, member 7 NYD-SP21 11q12.2 testes development-related NYD-SP21 MS4A5 11q12 membrane-spanning 4-domains, subfamily A, member 5 MS4A1 11q12.2-q13.1 membrane-spanning 4-domains, subfamily A, member 1 MS4A12 11q12.1 membrane-spanning 4-domains, subfamily A, member 12 MGC39681 11q12.2 hypothetical protein MGC39681 MS4A8B 11q12.1 membrane-spanning 4-domains, subfamily A, member 8B MGC35295 11q12.2 hypothetical protein MGC35295 LOC341116 11q12.2 similar to Membrane-spanning 4-domains subfamily A member 10 MGC2574 11q12.2 hypothetical protein MGC2574 GPR44 11q12-q13.3 G protein-coupled receptor 44 LOC255714 11q12.2 similar to ZP1 precursor NMP200 11q12.2 nuclear matrix protein NMP200 related to splicing factor PRP19 MGC5508 11q12.2 hypothetical protein MGC5508 GBP 11q12.2 likely ortholog of rat GRP78-binding protein SLC15A3 11q13.1 solute carrier family 15, member 3 CD6 11q13 CD6 antigen CD5 11q12.2 CD5 antigen (p56-62) FLJ20847 11q12.3 hypothetical protein FLJ20847 PGA5 11q13 pepsinogen 5, group I (pepsinogen A) FLJ32009 11q12.3 hypothetical protein FLJ32009 DDB1 11q12-q13.1 damage-specific DNA binding protein 1, 127kDa DKFZP586B1621 11q12.3 DKFZP586B1621 protein MGC20446 11q12.3 hypothetical protein MGC20446
    RNA
    TRANSCRIPTS type messenger
    text two transcripts encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 3331 - 297 - -
    8 - 3594 - 297 - -
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   lowly
    Digestivepharynx   highly
    Lymphoid/Immunelymph node   highly
     spleen   highly
     thymus   highly
    Nervousbrain   lowly
    Reproductivemale systemtestis  lowly
    Urinarykidney   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Connective    
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
     mast cell
    Lymphoid/ImmuneB cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a short intracellular domain
  • four transmembrane segments (4TM)
  • a long cytoplasmic tail, involved in intracellular signaling
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Ms4a2 (83 pc)
    Homologene
    FAMILY
  • MS4A family
  • CATEGORY signaling , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in the regulation of B cell activation and proliferation
  • B cell-specific membrane protein that functions in store-operated calcium entry and serves as a useful target for antibody-mediated therapeutic depletion of B cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • component of oligomeric cell surface complex involved in signal transduction
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
  • constitutively raft-associated
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CVID5
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS