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FLASH GENE
Symbol GIF contributors: mct - updated : 09-03-2016
HGNC name gastric intrinsic factor (vitamin B synthesis)
HGNC id 4268
Corresponding disease
GIF intrinsic factor deficiency
MGA3 megaloblastic anemia due to intrinsic factor deficiency 3
Location 11q12.1      Physical location : 59.596.747 - 59.612.974
Synonym name
  • haptocorrin
  • gastric intrinsic factor
  • Synonym symbol(s) IFMH, IF, INF, TCN3
    DNA
    TYPE functioning gene
    STRUCTURE 16.27 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    LOC390192 11 LOC390192 LOC219976 11q12.2 similar to FLJ00239 protein LOC390193 11 similar to olfactory receptor MOR215-1 LOC390194 11 similar to olfactory receptor MOR215-1 LOC390195 11 similar to Olfactory receptor 5AN1 LOC390196 11 similar to seven transmembrane helix receptor LOC219981 11q12.2 similar to Olfactory receptor 5A2 LOC219982 11q12.2 similar to Olfactory receptor 5A1 (OST181) LOC219983 11q12.2 similar to Olfactory receptor 4D6 LOC390197 11 similar to seven transmembrane helix receptor LOC390198 11 similar to seven transmembrane helix receptor LOC219986 11q12.2 similar to seven transmembrane helix receptor LOC390199 11 similar to Olfactory receptor 4D9 LOC390200 11 similar to olfactory receptor MOR239-1 OSBP 11q12.2 oxysterol binding protein FLJ36874 11q12.2 hypothetical protein FLJ36874 LOC390201 11 similar to seven transmembrane helix receptor LOC390202 11 similar to olfactory receptor GA_x6K02T2RE5P-2207258-2206302 STX3A 11q12.1 syntaxin 3A MRPL16 11q12-q13.1 mitochondrial ribosomal protein L16 GIF 11q12.2 gastric intrinsic factor (vitamin B synthesis) TCN1 11q11-q12 transcobalamin I (vitamin B12 binding protein, R binder family) LOC390203 11 similar to hypothetical protein FLJ13352 LOC255649 11q12.2 hypothetical LOC255649 FLJ36198 11q12.2 hypothetical protein FLJ36198 MS4A3 11q12 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) MS4A2 11q12.2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) MS4A6A 11q12.1 membrane-spanning 4-domains, subfamily A, member 6A LOC390204 11 similar to membrane-spanning 4-domains, subfamily A, member 4 isoform b; membrane-spanning 4-domains, subfamily A, member 4A; four-span transmembrane protein; Fc epsilon receptor beta subunit homolog
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1536 - 417 - 2004 14576042
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandular  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY eukaryotic cobalamin transport proteins family
    CATEGORY secretory , transport carrier
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • involved in vitamin B synthesis
  • GIF is a fucosylated protein needed for B12 absorption
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GIF , MGA3
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS