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Symbol ZNF148 contributors: mct/npt - updated : 31-01-2018
HGNC name zinc finger protein 148
HGNC id 12933
Corresponding disease
GDACCF global developmental delay, absent or hypoplastic corpus callosum, and dysmorphic facies
Location 3q21.2      Physical location : 124.944.514 - 125.094.198
Synonym name
  • zinc binding protein 89
  • beta enolase factor 1
  • zinc finger protein 148 (pHZ-52)
  • CACCC box-binding protein
  • CLL-associated antigen KW-10
  • ZBP-89 delta-Nter isoform
  • Synonym symbol(s) BERF1, PHZ52, ZBP89, BFCOL1, ZFP148, ZBP-89, HT-BETA, TCRBV8BP
    TYPE functioning gene
    STRUCTURE 149.69 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   transcription factor
    text structure
  • ZNF148 is a regulator of PDCD4 by binding to the basal promoter either alone or by interacting with Sp family members
  • MAPPING cloned Y linked N status confirmed
    Map cen - UMPS UMPS - D3S1269 - D3S1551 - ZNF148 - D3S1765 - qter
    Authors Law(98)
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 9573 88.9 794 - 2016 26891870
    10 - 9890 - 794 - 2016 26891870
    10 - 9690 - 794 - 2016 26891870
    8 - 9413 - 794 - 2016 26891870
    10 - 9663 - 794 - 2016 26891870
    9 - 9568 - 794 - 2016 26891870
    10 - 9685 - 794 - 2016 26891870
    9 - 9494 - 794 - 2016 26891870
    8 - 9492 - 794 - 2016 26891870
    9 - 9803 - 794 - 2016 26891870
    9 - 9624 - 794 - 2016 26891870
    8 - 9447 - 752 - 2016 26891870
    9 - 3283 - 235 - 2016 26891870
    Type widely
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly
    Endocrineneuroendocrinepituitary  highly
    Lymphoid/Immunelymph node   highly
    Reproductivemale systemprostate  moderately
    Urinarykidney   moderately
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    cell lineage T cell lineages
    cell lines
    at STAGE
    physiological period embryo
    Text neural tube
  • zinc finger protein, C2H2 type, Krüppel-like, four tandem binding domains
  • two synergy control (SC) motifs that flank the zinc finger cluster DNA binding domain, in the N-terminal half of the protein surrounding the zinc finger DNA binding domain
  • conjugated MetalloP
    interspecies homolog to rattus Zbp89
    murine Zfp148
  • krueppel C2H2-type zinc-finger protein family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • functioning as a beta enolase repressor factor 1 (and repressor of stromelysin and gastrin)
  • repressing gastrin gene expresion
  • sequence-specific regulator that plays key roles in cellular growth and differentiation especially in endodermal and germ cell lineages
  • involved in upregulation of MMP3 and in tumor metastasis
  • with GATA1, cooccupy cis-regulatory elements of certain erythroid and megakaryocyte-specific genes, including an enhancer of the GATA1 gene itself (Woo 2008)
  • novel transcription factor involved in erythroid and megakaryocytic development and can serves a cooperative function with GATA1 and/or FOG1 in a developmental stage-specific manner (Woo 2008)
  • activating role for ZNF1489 in human globin gene regulation and erythroid differentiation
  • Krüppel-type zinc-finger transcription factor, found to participate in tumor development, invasion and metastasis
  • plays a critical role in erythroid lineage development
  • is a transcription factor with roles in regulating vital cellular processes, acting through complex interactions with other proteins to ensure appropriate expression of tightly regulated genes
  • controls likely the fate of newly transformed intestinal tumor cells by repressing TP53
  • is a hitherto unrecognized but crucial transcription factor in the development of the corpus callosum
  • ZNF148 and TOP2A regulate each other through Competing endogenous RNA (ceRNA) regulatory mechanism in colorectal cancer (CRC), which has biological effects on cell proliferation.
  • plays a direct role in human muscle cell differentiation, and is a negative regulator of human muscle differentiation
  • CELLULAR PROCESS nucleotide, transcription, regulation
    text transcriptional repressor
    a component component of multiprotein complexes involving GATA1 and friend of GATA1 (FOG1) in erythroid and megakaryocytic cells (Ohneda 2009)
    small molecule metal binding, other,
  • Zn2+
  • Krüppel-type zinc-finger transcription factor that binds to GC-rich sequences
  • protein
  • repressor of basal and inducible induction of gastrin and of vimentin
  • interacts with UBC9 and is a target of sumoylation at two conserved SC motifs ( target of SUMO modification, and all three SUMO isoforms can be conjugated to ZNF148)
  • GATA1-associated transcription factor in both erythroid cells and megakaryocytes (Ohneda 2009)
  • alternative binding of ZNF1489 or SP1 to the described region in the IRS2 promoter regulates neuronal IRS2 expression in a PI3K-dependent manner
  • reduces HDAC3 by degrading IkappaB in the presence of PIN1
  • role for ZNF148 in regulation of MMP1 expression, suggesting the possibility of a larger role for ZNF148 in inflammation through interactions with NFKB1
  • cell & other
    corresponding disease(s) GDACCF
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in solid tumor
    tumoral     --low  
    in clear cell renal cell carcinoma (CCRCC)
    Variant & Polymorphism
    Candidate gene
  • could be served as a promising biomarker for prediction of distal metastasis and prognosis of patient with CCRCC
  • Therapy target
    targeting ZNF148 might be useful in the treatment of colorectal cancer