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FLASH GENE
Symbol ZNF148 contributors: mct/npt - updated : 31-01-2018
HGNC name zinc finger protein 148
HGNC id 12933
Corresponding disease
GDACCF global developmental delay, absent or hypoplastic corpus callosum, and dysmorphic facies
Location 3q21.2      Physical location : 124.944.514 - 125.094.198
Synonym name
  • zinc binding protein 89
  • beta enolase factor 1
  • zinc finger protein 148 (pHZ-52)
  • CACCC box-binding protein
  • CLL-associated antigen KW-10
  • ZBP-89 delta-Nter isoform
  • Synonym symbol(s) BERF1, PHZ52, ZBP89, BFCOL1, ZFP148, ZBP-89, HT-BETA, TCRBV8BP
    DNA
    TYPE functioning gene
    STRUCTURE 149.69 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    Binding site   transcription factor
    text structure
  • ZNF148 is a regulator of PDCD4 by binding to the basal promoter either alone or by interacting with Sp family members
  • MAPPING cloned Y linked N status confirmed
    Map cen - UMPS UMPS - D3S1269 - D3S1551 - ZNF148 - D3S1765 - qter
    Authors Law(98)
    Physical map
    FLJ12892 3q21.2 hypothetical protein FLJ12892 ROPN1 3q21.2 ropporin, rhophilin associated protein 1 HAPIP q21.1-q21.2 huntingtin-associated protein interacting protein (duo) TRAD 3q21.2 serine/threonine kinase with Dbl- and pleckstrin homology domains UMPS 3q13 uridine monophosphate synthetase (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase) ITGB5 3q21.2 integrin, beta 5 MUC13 3q13.3 mucin 13, epithelial transmembrane HEG 3q21.2 HEG homolog SLC12A8 3q21 solute carrier family 12 (potassium/chloride transporters), member 8 ZNF148 3q21 zinc finger protein 148 (pHZ-52) SNX4 3q21.1-q21.3 sorting nexin 4 OSBPL11 3q21 oxysterol binding protein-like 11 LOC389144 3 similar to seven transmembrane helix receptor OR7E93P 3q13.33 olfactory receptor, family 7, subfamily E, member 93 pseudogene OR7E53P 3q13.33 olfactory receptor, family 7, subfamily E, member 53 pseudogene OR7E97P 3q13.33 olfactory receptor, family 7, subfamily E, member 97 pseudogene LOC344729 3q21.2 similar to chromosome 11 open reading frame2; chromosome  11 open reading frame2 LOC389145 3 LOC389145 LOC165622 3q21.2 similar to Alkaline sphingomyelinase LOC200810 3q21.2 similar to asparagine-linked glycosylation 1 homolog (yeast, beta-1,4-mannosyltransferase); beta-1,4 mannosyltransferase LOC152015 3q21.2 similar to AKAP-binding sperm protein ropporin FLJ20473 FTHFD 3q21.2 formyltetrahydrofolate dehydrogenase KLF15 3q13-q21 Kruppel-like factor 15 FLJ40083 3q21.3 hypothetical protein FLJ40083 FLJ20123 3q21.3 hypothetical protein FLJ20123 MGC11349 3q21.3 hypothetical protein MGC11349 FLJ31300 3q21.3 hypothetical protein FLJ31300 CHST13 3q21.3 carbohydrate (chondroitin 4) sulfotransferase 13 MGC34728 3q21.3 hypothetical protein MGC34728
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 9573 88.9 794 - 2016 26891870
    10 - 9890 - 794 - 2016 26891870
    10 - 9690 - 794 - 2016 26891870
    8 - 9413 - 794 - 2016 26891870
    10 - 9663 - 794 - 2016 26891870
    9 - 9568 - 794 - 2016 26891870
    10 - 9685 - 794 - 2016 26891870
    9 - 9494 - 794 - 2016 26891870
    8 - 9492 - 794 - 2016 26891870
    9 - 9803 - 794 - 2016 26891870
    9 - 9624 - 794 - 2016 26891870
    8 - 9447 - 752 - 2016 26891870
    9 - 3283 - 235 - 2016 26891870
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly
    Endocrineneuroendocrinepituitary  highly
    Lymphoid/Immunelymph node   highly
    Reproductivemale systemprostate  moderately
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Muscularstriatumskeletal  
    cell lineage T cell lineages
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text neural tube
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • zinc finger protein, C2H2 type, Krüppel-like, four tandem binding domains
  • two synergy control (SC) motifs that flank the zinc finger cluster DNA binding domain, in the N-terminal half of the protein surrounding the zinc finger DNA binding domain
  • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to rattus Zbp89
    murine Zfp148
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • functioning as a beta enolase repressor factor 1 (and repressor of stromelysin and gastrin)
  • repressing gastrin gene expresion
  • sequence-specific regulator that plays key roles in cellular growth and differentiation especially in endodermal and germ cell lineages
  • involved in upregulation of MMP3 and in tumor metastasis
  • with GATA1, cooccupy cis-regulatory elements of certain erythroid and megakaryocyte-specific genes, including an enhancer of the GATA1 gene itself (Woo 2008)
  • novel transcription factor involved in erythroid and megakaryocytic development and can serves a cooperative function with GATA1 and/or FOG1 in a developmental stage-specific manner (Woo 2008)
  • activating role for ZNF1489 in human globin gene regulation and erythroid differentiation
  • Krüppel-type zinc-finger transcription factor, found to participate in tumor development, invasion and metastasis
  • plays a critical role in erythroid lineage development
  • is a transcription factor with roles in regulating vital cellular processes, acting through complex interactions with other proteins to ensure appropriate expression of tightly regulated genes
  • controls likely the fate of newly transformed intestinal tumor cells by repressing TP53
  • is a hitherto unrecognized but crucial transcription factor in the development of the corpus callosum
  • ZNF148 and TOP2A regulate each other through Competing endogenous RNA (ceRNA) regulatory mechanism in colorectal cancer (CRC), which has biological effects on cell proliferation.
  • plays a direct role in human muscle cell differentiation, and is a negative regulator of human muscle differentiation
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text transcriptional repressor
    PATHWAY
    metabolism
    signaling
    a component component of multiprotein complexes involving GATA1 and friend of GATA1 (FOG1) in erythroid and megakaryocytic cells (Ohneda 2009)
    INTERACTION
    DNA
    RNA
    small molecule metal binding, other,
  • Zn2+
  • Krüppel-type zinc-finger transcription factor that binds to GC-rich sequences
  • protein
  • repressor of basal and inducible induction of gastrin and of vimentin
  • interacts with UBC9 and is a target of sumoylation at two conserved SC motifs ( target of SUMO modification, and all three SUMO isoforms can be conjugated to ZNF148)
  • GATA1-associated transcription factor in both erythroid cells and megakaryocytes (Ohneda 2009)
  • alternative binding of ZNF1489 or SP1 to the described region in the IRS2 promoter regulates neuronal IRS2 expression in a PI3K-dependent manner
  • reduces HDAC3 by degrading IkappaB in the presence of PIN1
  • role for ZNF148 in regulation of MMP1 expression, suggesting the possibility of a larger role for ZNF148 in inflammation through interactions with NFKB1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GDACCF
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in solid tumor
    tumoral     --low  
    in clear cell renal cell carcinoma (CCRCC)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • could be served as a promising biomarker for prediction of distal metastasis and prognosis of patient with CCRCC
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    targeting ZNF148 might be useful in the treatment of colorectal cancer
    ANIMAL & CELL MODELS