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FLASH GENE
Symbol ZNF148 contributors: mct/npt - updated : 31-01-2018
HGNC name zinc finger protein 148
HGNC id 12933
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • zinc finger protein, C2H2 type, Krüppel-like, four tandem binding domains
  • two synergy control (SC) motifs that flank the zinc finger cluster DNA binding domain, in the N-terminal half of the protein surrounding the zinc finger DNA binding domain
  • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to rattus Zbp89
    murine Zfp148
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • functioning as a beta enolase repressor factor 1 (and repressor of stromelysin and gastrin)
  • repressing gastrin gene expresion
  • sequence-specific regulator that plays key roles in cellular growth and differentiation especially in endodermal and germ cell lineages
  • involved in upregulation of MMP3 and in tumor metastasis
  • with GATA1, cooccupy cis-regulatory elements of certain erythroid and megakaryocyte-specific genes, including an enhancer of the GATA1 gene itself (Woo 2008)
  • novel transcription factor involved in erythroid and megakaryocytic development and can serves a cooperative function with GATA1 and/or FOG1 in a developmental stage-specific manner (Woo 2008)
  • activating role for ZNF1489 in human globin gene regulation and erythroid differentiation
  • Krüppel-type zinc-finger transcription factor, found to participate in tumor development, invasion and metastasis
  • plays a critical role in erythroid lineage development
  • is a transcription factor with roles in regulating vital cellular processes, acting through complex interactions with other proteins to ensure appropriate expression of tightly regulated genes
  • controls likely the fate of newly transformed intestinal tumor cells by repressing TP53
  • is a hitherto unrecognized but crucial transcription factor in the development of the corpus callosum
  • ZNF148 and TOP2A regulate each other through Competing endogenous RNA (ceRNA) regulatory mechanism in colorectal cancer (CRC), which has biological effects on cell proliferation.
  • plays a direct role in human muscle cell differentiation, and is a negative regulator of human muscle differentiation
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text transcriptional repressor
    PATHWAY
    metabolism
    signaling
    a component component of multiprotein complexes involving GATA1 and friend of GATA1 (FOG1) in erythroid and megakaryocytic cells (Ohneda 2009)
    INTERACTION
    DNA
    RNA
    small molecule metal binding, other,
  • Zn2+
  • Krüppel-type zinc-finger transcription factor that binds to GC-rich sequences
  • protein
  • repressor of basal and inducible induction of gastrin and of vimentin
  • interacts with UBC9 and is a target of sumoylation at two conserved SC motifs ( target of SUMO modification, and all three SUMO isoforms can be conjugated to ZNF148)
  • GATA1-associated transcription factor in both erythroid cells and megakaryocytes (Ohneda 2009)
  • alternative binding of ZNF1489 or SP1 to the described region in the IRS2 promoter regulates neuronal IRS2 expression in a PI3K-dependent manner
  • reduces HDAC3 by degrading IkappaB in the presence of PIN1
  • role for ZNF148 in regulation of MMP1 expression, suggesting the possibility of a larger role for ZNF148 in inflammation through interactions with NFKB1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GDACCF
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in solid tumor
    tumoral     --low  
    in clear cell renal cell carcinoma (CCRCC)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • could be served as a promising biomarker for prediction of distal metastasis and prognosis of patient with CCRCC
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    targeting ZNF148 might be useful in the treatment of colorectal cancer
    ANIMAL & CELL MODELS