basic FUNCTION
| functioning as a beta enolase repressor factor 1 (and repressor of stromelysin and gastrin) |
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repressing gastrin gene expresion |
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sequence-specific regulator that plays key roles in cellular growth and differentiation especially in endodermal and germ cell lineages |
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involved in upregulation of MMP3 and in tumor metastasis |
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with GATA1, cooccupy cis-regulatory elements of certain erythroid and megakaryocyte-specific genes, including an enhancer of the GATA1 gene itself (Woo 2008) |
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novel transcription factor involved in erythroid and megakaryocytic development and can serves a cooperative function with GATA1 and/or FOG1 in a developmental stage-specific manner (Woo 2008) |
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activating role for ZNF1489 in human globin gene regulation and erythroid differentiation |
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Krüppel-type zinc-finger transcription factor, found to participate in tumor development, invasion and metastasis |
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plays a critical role in erythroid lineage development |
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is a transcription factor with roles in regulating vital cellular processes, acting through complex interactions with other proteins to ensure appropriate expression of tightly regulated genes |
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controls likely the fate of newly transformed intestinal tumor cells by repressing TP53 |
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is a hitherto unrecognized but crucial transcription factor in the development of the corpus callosum |
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ZNF148 and TOP2A regulate each other through Competing endogenous RNA (ceRNA) regulatory mechanism in colorectal cancer (CRC), which has biological effects on cell proliferation. |
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plays a direct role in human muscle cell differentiation, and is a negative regulator of human muscle differentiation |