Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ZNF148 contributors: mct/npt - updated : 31-01-2018
HGNC name zinc finger protein 148
HGNC id 12933
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue  highly
Endocrineneuroendocrinepituitary  highly
Lymphoid/Immunelymph node   highly
Reproductivemale systemprostate  moderately
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
Muscularstriatumskeletal  
cell lineage T cell lineages
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text neural tube
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • zinc finger protein, C2H2 type, Krüppel-like, four tandem binding domains
  • two synergy control (SC) motifs that flank the zinc finger cluster DNA binding domain, in the N-terminal half of the protein surrounding the zinc finger DNA binding domain
  • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to rattus Zbp89
    murine Zfp148
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • functioning as a beta enolase repressor factor 1 (and repressor of stromelysin and gastrin)
  • repressing gastrin gene expresion
  • sequence-specific regulator that plays key roles in cellular growth and differentiation especially in endodermal and germ cell lineages
  • involved in upregulation of MMP3 and in tumor metastasis
  • with GATA1, cooccupy cis-regulatory elements of certain erythroid and megakaryocyte-specific genes, including an enhancer of the GATA1 gene itself (Woo 2008)
  • novel transcription factor involved in erythroid and megakaryocytic development and can serves a cooperative function with GATA1 and/or FOG1 in a developmental stage-specific manner (Woo 2008)
  • activating role for ZNF1489 in human globin gene regulation and erythroid differentiation
  • Krüppel-type zinc-finger transcription factor, found to participate in tumor development, invasion and metastasis
  • plays a critical role in erythroid lineage development
  • is a transcription factor with roles in regulating vital cellular processes, acting through complex interactions with other proteins to ensure appropriate expression of tightly regulated genes
  • controls likely the fate of newly transformed intestinal tumor cells by repressing TP53
  • is a hitherto unrecognized but crucial transcription factor in the development of the corpus callosum
  • ZNF148 and TOP2A regulate each other through Competing endogenous RNA (ceRNA) regulatory mechanism in colorectal cancer (CRC), which has biological effects on cell proliferation.
  • plays a direct role in human muscle cell differentiation, and is a negative regulator of human muscle differentiation
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    text transcriptional repressor
    PATHWAY
    metabolism
    signaling
    a component component of multiprotein complexes involving GATA1 and friend of GATA1 (FOG1) in erythroid and megakaryocytic cells (Ohneda 2009)
    INTERACTION
    DNA
    RNA
    small molecule metal binding, other,
  • Zn2+
  • Krüppel-type zinc-finger transcription factor that binds to GC-rich sequences
  • protein
  • repressor of basal and inducible induction of gastrin and of vimentin
  • interacts with UBC9 and is a target of sumoylation at two conserved SC motifs ( target of SUMO modification, and all three SUMO isoforms can be conjugated to ZNF148)
  • GATA1-associated transcription factor in both erythroid cells and megakaryocytes (Ohneda 2009)
  • alternative binding of ZNF1489 or SP1 to the described region in the IRS2 promoter regulates neuronal IRS2 expression in a PI3K-dependent manner
  • reduces HDAC3 by degrading IkappaB in the presence of PIN1
  • role for ZNF148 in regulation of MMP1 expression, suggesting the possibility of a larger role for ZNF148 in inflammation through interactions with NFKB1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GDACCF
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in solid tumor
    tumoral     --low  
    in clear cell renal cell carcinoma (CCRCC)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • could be served as a promising biomarker for prediction of distal metastasis and prognosis of patient with CCRCC
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    targeting ZNF148 might be useful in the treatment of colorectal cancer
    ANIMAL & CELL MODELS