basic FUNCTION
| promoting the repair of DNA double strand breaks by homologous recombination by faciliting |
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RAD51-dependent recombination repair |
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with BRCA2 protein are required for homologous recombination (but XRCC2 is not involved in transcription-associated recombination, TAR) |
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important function of XRCC2 is to enhance the activity of RAD51, so that the loss of XRCC2 results in a severe delay in the early response of RAD51 to DNA damage |
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RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3, play an essential role in the DNA repair reactions through homologous recombination |
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RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3 are key enzymes for DNA double-strand break repair |
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XRCC2 and XRCC3 complexes act at different stages of the homologous recombination (HR) pathway |
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integrally involved in HR and critical for the maintenance of genome integrity |
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XRCC2 regulates replication fork pogression during dinucleotide triphosphate (dNTP) alterations |
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RAD51B, RAD51C, RAD51D, XRCC2, XRCC3 sequentially orchestrate clinically relevant transactions at replication forks, cooperatively promoting fork remodeling and restart |