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FLASH GENE
Symbol XRCC2 contributors: mct/npt/pgu - updated : 11-12-2013
HGNC name X-ray repair complementing defective repair in Chinese hamster cells 2
HGNC id 12829
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies paralog to RAD51
Homologene
FAMILY
  • RECA family
  • RAD51 subfamily
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus
    text
  • XRCC2 and other HR proteins, including the key recombinase RAD51, co-localize with the centrosome
  • basic FUNCTION
  • promoting the repair of DNA double strand breaks by homologous recombination by faciliting
  • RAD51-dependent recombination repair
  • with BRCA2 protein are required for homologous recombination (but XRCC2 is not involved in transcription-associated recombination, TAR)
  • important function of XRCC2 is to enhance the activity of RAD51, so that the loss of XRCC2 results in a severe delay in the early response of RAD51 to DNA damage
  • RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3, play an essential role in the DNA repair reactions through homologous recombination
  • RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3 are key enzymes for DNA double-strand break repair
  • CELLULAR PROCESS nucleotide, repair, recombination
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    pathway in cells for the repair of severe DNA damage such as double-strand breaks
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RAD51D
  • HELQ is associated with the RAD51 paralogs RAD51B/C/D and XRCC2, and with the DNA damage-responsive kinase ATR
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) FANCR
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    cells deficient in XRCC2 show disruption of the centrosome, a key component of the mitotic apparatus
    Susceptibility
  • to breast cancer with younger-onset
  • to ovarian carcinoma
  • Variant & Polymorphism
  • R188H polymorphism increase the risk of breast cancer
  • XRCC2 rs3218536, R188H, showed some evidence of a protective association for the rare allele
  • XRCC2 (R188H) allele reduces risk to epithelial ovarian cancer, the increased XRCC2 activity with the R188H polymorphism may have clinical benefit in preventing cancer risk
  • XRCC2 SNPs may influence breast cancer risk and survival
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS