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FLASH GENE
Symbol XRCC2 contributors: mct/npt/pgu - updated : 11-12-2013
HGNC name X-ray repair complementing defective repair in Chinese hamster cells 2
HGNC id 12829
Corresponding disease
FANCR Fanconi anemia, complementation group R
Location 7q36.1      Physical location : 152.343.588 - 152.373.250
Synonym name
  • repair X-ray defect complementing defect in CHO cells 2
  • DNA repair protein XRCC2
  • RAD51-like
    • Synonym symbol(s) XRC2, DKFZp781P0919
    DNA
    TYPE functioning gene
    STRUCTURE 29.67 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - D7S676 - D7S688 - D7S505 - [D7S642 - D7S483 - D7S798 - D7S637 - D7S237 - D7S203 - D7S263 - qter
    Physical map
    LOC392152 7 similar to gastrulation brain homeobox 1 ASB10 7q35 ankyrin repeat and SOCS box-containing 10 LOC155046 7q36.1 similar to hypothetical protein 4931409K22 LOC346545 7q36.1 similar to hypothetical protein FLJ22527 ABCF2 7q35-q36 ATP-binding cassette, sub-family F (GCN20), member 2 CSGlcA-T 7q36.1 KIAA1402 protein SMARCD3 7q35-q36 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 NYREN18 7q36 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 LOC349136 7q36.1 hypothetical protein LOC349136 CRYGN 7q36.1 crystallin, gamma N RHEB 7q36 Ras homolog enriched in brain ETF1P2 7q11 eukaryotic translation termination factor 1 pseudogene 2 PRKAG2 7q36 protein kinase, AMP-activated, gamma 2 non-catalytic subunit GALNT15 7q36.2 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15 GALNT11 7q34-q36 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11) LOC392153 7 similar to TSH receptor suppressor element-binding protein-1; TSEP-1 LOC389600 7 LOC389600 MLL3 7q36 myeloid/lymphoid or mixed-lineage leukemia 3 LOC220832 7q36.2 similar to Fatty acid-binding protein, epidermal (E-FABP) (Psoriasis-associated fatty acid-binding protein homolog) (PA-FABP) LOC155100 7q36.2 similar to T-complex protein 1 XRCC2 7q36.1 X-ray repair complementing defective repair in Chinese hamster cells 2 LOC392154 7 similar to ATP synthase B chain, mitochondrial precursor ARP3BETA 7q346 similar to ATP synthase B chain, mitochondrial precursor LOC392155 7 similar to SMT3 suppressor of mif two 3 homolog 2 LOC346547 7q36.2 similar to envelope protein LOC392156 7 similar to ppg3
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 3094 31.8 280 - 1995 7607692
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Nervousbrain    
    Reproductivefemale systembreastmammary gland highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    intraspecies paralog to RAD51
    Homologene
    FAMILY
  • RECA family
  • RAD51 subfamily
    • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus
    text
  • XRCC2 and other HR proteins, including the key recombinase RAD51, co-localize with the centrosome
    • basic FUNCTION
  • promoting the repair of DNA double strand breaks by homologous recombination by faciliting
  • RAD51-dependent recombination repair
  • with BRCA2 protein are required for homologous recombination (but XRCC2 is not involved in transcription-associated recombination, TAR)
  • important function of XRCC2 is to enhance the activity of RAD51, so that the loss of XRCC2 results in a severe delay in the early response of RAD51 to DNA damage
  • RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3, play an essential role in the DNA repair reactions through homologous recombination
  • RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3 are key enzymes for DNA double-strand break repair
    • CELLULAR PROCESS nucleotide, repair, recombination
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    pathway in cells for the repair of severe DNA damage such as double-strand breaks
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RAD51D
  • HELQ is associated with the RAD51 paralogs RAD51B/C/D and XRCC2, and with the DNA damage-responsive kinase ATR
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) FANCR
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    cells deficient in XRCC2 show disruption of the centrosome, a key component of the mitotic apparatus
    Susceptibility
  • to breast cancer with younger-onset
  • to ovarian carcinoma
    • Variant & Polymorphism
  • R188H polymorphism increase the risk of breast cancer
  • XRCC2 rs3218536, R188H, showed some evidence of a protective association for the rare allele
  • XRCC2 (R188H) allele reduces risk to epithelial ovarian cancer, the increased XRCC2 activity with the R188H polymorphism may have clinical benefit in preventing cancer risk
  • XRCC2 SNPs may influence breast cancer risk and survival
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS