basic FUNCTION
| promoting the repair of DNA double strand breaks by homologous recombination by faciliting |
|
RAD51-dependent recombination repair |
|
with BRCA2 protein are required for homologous recombination (but XRCC2 is not involved in transcription-associated recombination, TAR)  |
|
important function of XRCC2 is to enhance the activity of RAD51, so that the loss of XRCC2 results in a severe delay in the early response of RAD51 to DNA damage  |
|
RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3, play an essential role in the DNA repair reactions through homologous recombination  |
|
RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3 are key enzymes for DNA double-strand break repair  |
|
XRCC2 and XRCC3 complexes act at different stages of the homologous recombination (HR) pathway  |
|
integrally involved in HR and critical for the maintenance of genome integrity  |
|
XRCC2 regulates replication fork pogression during dinucleotide triphosphate (dNTP) alterations  |
|
RAD51B, RAD51C, RAD51D, XRCC2, XRCC3 sequentially orchestrate clinically relevant transactions at replication forks, cooperatively promoting fork remodeling and restart  |